Mebeverine has been investigated for the treatment of Irritable Bowel Syndrome and Post-cholecystectomy* Gastrointestinal Spasms.




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Generic Name:                   Mebeverine HCl

Therapeutic Category:    Gastrointestinal Anticholinergics/Antispasmodics

Pharmacological Class:   Cholinergic muscarinic antagonist

Composition:                      Each film coated tablet contains Mebeverine HCl 135 mg.

Pregnancy Category:       Not Specified

Presentation:                      Available in the pack size as 10 tablets X 10 blisters


Mechanism of Action

Mebeverine is an anticholinergic but its mechanism of action is not known; it appears to work directly on smooth muscle within the gastrointestinal tract and may have an anesthetic effect, may affect calcium channels, and may affect muscarinic receptors. It relieves spasm without affecting normal gut motility.




  • Irritable bowel syndrome /Chronic irritable colon / Spastic colon
  • Gastrointestinal spasm
  • Mucous colitis*
  • Spastic constipation



Route of administration: Oral

Children below 10 years: Not Recommended

Adult and child over 10 years: 135–150 mg three times a day preferably 20 minutes before meals.


Absorption: Rapidly absorbed in GIT

Metabolism: Metabolized by esterases

Protein binding: Approximately 11-14%

Route of elimination: Renal

Adverse Effects

  • Hypersensitivity reactions and allergic reactions, immune system disorders, skin disorders including hives, edema and widespread rashes.
  • Additionally, the following adverse effects have been reported: heartburn, indigestion, tiredness, diarrhea, constipation, loss of appetite, general malaise, dizziness, insomnia, headache, and decreased pulse rate.

It does not have systemic anticholinergic side effects.


IBOSYN is contraindicated in the following situations:

  • Hypersensitivity to the active substance or to any of the excipients.
  • Pregnant, lactating mothers
  • Children below 10 years


Cholecystectomy: It refers to the surgical removal of the gall bladder.

Mucous colitis: A common gastrointestinal disorder involving an abnormal condition of gut contractions (motility) and gut sensation (hypersensitivity)