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Dove
Dove
Antispasmodic

DOVE

Drotaverine (INN, also known as drotaverine) is an antispasmodic drug, structurally related to papaverine. Drotaverine is a selective inhibitor of phosphodiesterase-4, and has no anticholinergic effects. Drotaverine has been shown to possess dose-dependent analgesic effects in animal models. 

barcode

DOVE 40/80

Generic Name:                               Drotaverine HCl

Therapeutic Category:                Antispasmodic

Pharmacological Class:               Cholinergic Muscarinic Antagonist

Composition:                                  Dove 40

Each film coated tablet contains Drotaverine HCl 40mg.

Dove 80

Each film coated tablet contains Drotaverine HCl 80mg.

Pregnancy Category:                   C

Presentation:                                  Available in the pack size as 10 tablets X 20 blisters

 

Mechanism of Action

  • Cyclic AMP (cAMP) is a second messenger to regulate a large number of key processes.
  • Phosphodiesterase (PDE) hydrolyses cAMP, thus decreasing its concentration in the cells.
  • cAMP and Ca++ imbalance results in smooth muscle spasm and pain.
  • Drotaverine has antispasmodic effect mediated via inhibition of phosphodiesterase-IV, specific for smooth muscle.
  • Drotaverine acts to correct cyclic AMP and Ca imbalance at the spastic site, thereby relieving smooth muscle spasm and pain.
  • It has a rapid and direct action on the smooth muscle.

Indications

  • Intestinal and Biliary renal colics*
  • Irritable Bowel Syndrome(IBS)
  • Uterine Spasm

 

            Dosage

Route of administration: Oral

Children more than 6 years:  40 mg orally 3 times a day tid.

No data regarding the Pediatric dosage details of Drotaverine is available.

The medication can be taken with or without food.

Pharmacokinetics                                                                                      

Absorption: Rapidly absorbed from the GI tract 

Protein binding: Approximately 80-95%

Metabolism: Hepatic

Route of elimination: >50% in urine and ~30% in bile

Half-life: 7-12 hours

Adverse Effects

Dizziness, Vertigo, Headache, Nausea, Vomiting, Palpitation, Constipation, Insomnia, Dry mouth, Hypotension

Contraindications

DOVE is contraindicated in the following conditions:

  • Cardiac dysfunction
  • Renal insufficiency
  • Hepatic insufficiency

Interactions

No data regarding the interactions of Drotaverine was found.

*Terminologies:

Colic: severe pain in the abdomen caused by wind or obstruction in the intestines.

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