cofsy D
cofsy D


Levodropropizine is a cough suppressant. It is the levo isomer of dropropizine. It acts as a peripheral antitussive, with no action in the central nervous system.


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Generic Name:                                 Levodropropizine

Therapeutic Category:                   Antitussive 

Pharmacological Class:                  Cough Suppressant

Composition:                                    Each 5 ml contains Levodropropizine BP 30 mg.

Pregnancy Category:                      D

Presentation:                                   100 ml bottle with a measuring cap 


Mechanism of Action

It reduces cough by:

  • Peripheral anti-tussive drugs act on chemical and mechanical receptors mainly located in the larynx and trachea lacking effects on the central nervous system, which make them more tolerable.
  • Interfering with stimulus activation of peripheral endings of sensory nerves.
  • Acts as a peripheral antitussive, with no action in the CNS 
  • Does not cause side effects such as constipation or respiratory depression which can be produced by opioid antitussives such as codeine and its derivatives.


  • Dry irritating cough



Route of administration: Oral

As a cough suppressant (Adults): 60 mg of COFSY-D, thrice daily. The duration should not exceed more than seven days.

As a cough suppressant (Pediatrics): 

For children >2 years: 1 mg/kg, thrice daily.

For children >12 yearsconsider administration of 60 mg of COFSY-D, thrice daily. 

The duration should not exceed more than seven days.


Absorption: Rapidly absorbed in GIT

Protein binding: Approximately 11-14%

Route of elimination: Renal

Adverse Effects

The symptomatic adverse reactions produced by COFSY-D are more or less tolerable. These include: 

Weakness, Dizziness, Headache, Drowsiness, Fatigue, Nausea, Vomiting, Diarrhea, Palpitation, Heart burn, dizziness, Weakness. 


COFSY-D is contraindicated in the following situations:

  • Excessive mucus discharge and limited muco-ciliary function. 
  • Severe liver impairment.
  • Should not be given in pregnant and lactating mothers


  • May interact with alcohols, sedatives, hypnotics and anti-histamines.