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What is Sidaze and what is it used for?

Sidaze contains Serratiopeptidase 5/10 mg in tablet form. It is a proteolytic enzyme and is used for painful conditions including back pain, osteoarthritis, rheumatoid arthritis, osteoporosis, fibromyalgia, carpel tunnel syndrome, migraine headache, and tension headache, oral surgery.

It is also used for conditions that involve pain and swelling (inflammation) including sinusitis, laryngitis, sore throat, ear infections, swelling after surgery, swelling of a vein with the formation of a blood clot (thrombophlebitis), and inflammatory bowel disease (IBD) including ulcerative colitis and Crohn’s disease.


How does it work?

Sidaze is an enzyme that works by breaking down the chemical messengers involved in pain and inflammation (redness and swelling). It also acts by enhancing blood circulation. Serratiopeptidase has anti-inflammatory, anti-edemic and fibrinolytic activity and act rapidly on localized inflammation.

 How to take Sidaze?

Adults: The recommended dose is 5-10 mg 3 times per day.

Children: The drug is not used in children due to the absence of clinical data

It is administered after meal.


What if you miss a dose?

If you forget to take a dose of Sidaze, do not worry. Just take the next dose at the usual time. Do not take a double dose to make up for a forgotten dose.              


What to do in case of overdose?

In case of overdose, contact your doctor or pharmacist if you have taken more Lactulose than you should.

What do you need to know before you take Sidaze?

Do not take Sidaze:

  • if you are allergic to serratiopeptidase or any of the other ingredients of this medicine


Warning and Precautions

Talk to your doctor or pharmacist before taking Sidaze:

  • Pregnancy and lactation women take with caution
  • Who have severe hepatic or renal disease take medicine according to practitioner advice
  • Bleeding disorders: This medicine might interfere with blood clotting, so some researchers worry that it might make bleeding disorders worse. If you have a bleeding disorder, check with your healthcare provider before using the medicine.
  • Surgery: Sidaze might interfere with blood clotting. There is a concern that it might increase bleeding during and after surgery. Stop using this medication at least 2 weeks before a scheduled surgery.


Sidaze and other medications

Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicine.


Pregnancy and breast-feeding

Not enough is known about the use of serratiopeptidase during pregnancy and breast-feeding. Stay on the safe side and avoid use.


Driving and using machines

Sidaze will not affect your ability to drive safely or use machines.


What are the possible side effects?

  • Gastro-intestinal disorders: diarrhea, nausea, vomiting, anorexia, and epigastric discomfort, abdominal pain.
  • Respiratory system disorders: nasal bleeding, streaks of blood in sputum, acute eosinophil pneumonia.
  • Skin: rash, itching, redness of skin.


Mechanism of action:

This anti-inflammatory proteolytic enzyme binds to the alpha-2-macroglobulin in the blood, which helps to mask its antigenicity. Then it is slowly transferred to the site of inflammation. Serratiopeptidase hydrolyze bradykinin, histamine, serotonin responsible for edema. It reduces swelling, improves microcirculation and expectoration of sputum. Due to this action Serratiopeptidase has anti-inflammatory, anti-oedemic and fibrinolytic activity and act rapidly on localized inflammation.


Elimination of inflammatory edema and swelling: Improves the circulation at the inflammatory focus by breaking down abnormal exudates (contains water, blood<proteins, WBC, platelets) which gets deposited in tissue.


Acceleration of liquefaction and elimination of sputum, pus and hematoma:  Accelerates the elimination of sputum, pus and hematoma*by breaking down and liquefying mucous secretions and fibrin (product of coagulation) clots.


Enhancement of the action of antibiotics: Increases the concentration of antibiotics in the focus of infection.


Pharmacokinetic properties:

Absorption:  Absorbed through the intestines and transported directly into the bloodstream in an enzymatically active form.

Duration of action: 6 hours

Excretion: Excreted with the bile in active form, and is detected in urine in insignificant quantity

Elimination Half-life:  1-4 hours


Sidaze and other medicines

This medication might decrease blood clotting. Therefore, taking Sidaze along with medications that also slow clotting might increase the chances of bruising and bleeding. Some medications that slow blood clotting include aspirin, clopidogrel, diclofenac, ibuprofen, naproxen, dalteparin, enoxaparin, heparin, warfarin and others.