BACMAX

Generic Name:                   Cefpodoxime Proxetil

Therapeutic Category:    Antibiotics

Pharmacological Class:   Second Generation Cephalosporin

Composition:                      Bacmax RPOS

                                                Each 5 ml of reconstituted suspension contains Cefpodoxime Proxetil USP equivalent to Cefpodoxime Proxetil 50 mg

Presentation:                      Available in 60 ml bottle with a measuring cap

Mechanism of Action

Cefpodoxime is a bactericidal agent that acts by inhibition of bacterial cell wall synthesis. Cefpodoxime has activity in the presence of some beta-lactamases, both penicillinases and cephalosporinases, of Gram-negative and Gram-positive bacteria.

Indications 

• Lower respiratory tract infections: Acute community acquired pneumonia, acute bacterial exacerbation of chronic bronchitis 
• Upper respiratory tract infections: Acute otitis media, acute maxillary sinusitis, pharyngitis, tonsillitis. 
• Uncomplicated urinary tract infections: Cystitis, Pyuria. 
• Skin and soft tissue infections: Furuncle, cellulitis, subcutaneous abscess, infectious atheroma & periproctal abscess.

Dosage

 Route of administration: Oral

BACMAX RPOS

Adults and Elderly:

Not applicable for this product

Infants (>2 months) and Children (up to 11 years):

The recommended mean dosage for children is 8mg/kg/day, administered in two divided doses at 12-hour intervals.

The following table provides dosage regimen for children as per the bodyweight graduations provided on the measuring cap:

Direction for Reconstitution

• Shake the bottle until the powder flows freely.
• Boil the water and let it cool down at room temperature.
• Add approximately one half of the total water required for reconstitution. Shake vigorously to suspend powder.
• Add remaining water up to the mark and shake vigorously.
• This provides 60 ml of solution.

Note: Store the suspension at 2-8⁰C

    Do not use the suspension for more than 7 days

Pharmacokinetics

Absorption: Absorbed via the GI tract. Absorption and mean peak plasma levels increase when drug is given with food. 

Distribution: Widely distributed to most tissues and fluids. Adequate data on CSF levels are not available.

Protein binding: 22 to 33% in serum and from 21 to 29% in plasma

Metabolism: De-esterified to its active metabolite, cefpodoxime

Route of elimination: Renal

Half-life: 2.09 to 2.84 hours

Adverse Effects

Common side-effects are:

• Nausea, vomiting, stomach pain, mild diarrhea, bloating, gas, constipation
• diaper rash; mild itching or skin rash
• stiff or tight muscles, back pain, muscle pain
• headache, tired feeling
• anxiety, nervousness, feeling restless or hyperactive
• dizziness, spinning sensation
• dry mouth, unusual or unpleasant taste in your mouth
• white patches or sores inside your mouth or on your lips

 Contraindications

BACMAX is contraindicated in the following situations:

• Hypersensitivity to cefpodoxime or to any of the components of the formulation.
• Safety of Cefpodoxime is not established in infants under the age of 2 months.

Precautions

• Bacterial or fungal overgrowth of non-susceptible organisms may occur with prolonged or repeated therapy
• Use with caution in patients with history of penicillin allergy
• Use caution in patients with history of beta-lactam allergy, especially IGE mediated reactions, including angioedema, anaphylaxis, urticaria)
• Some dosage forms may contain the metabolite of benzyl alcohol benzoic acid; large amounts of benzyl alcohol associated with potentially fatal toxicity (gasping syndrome) in neonates; avoid or use dosage forms containing benzyl alcohol derivative with caution in neonates

Drug Interactions

• Antacids, H2 antagonists, oral anticholinergics may decrease efficacy of Cefpodoxime. 
• It may be potentiated by probenecid. 
• Also, administration of concomitant diuretics, other nephrotoxic drugs must be avoided.*Terminologies:

*Terminologies:

Cystitis: An inflammation of the bladder.

Prostatitis: The inflammation (swelling) of the prostate gland.

Plague: An infectious disease caused by the bacterium Yersinia pestis.

Tendinitis: The inflammation of a tendon, most commonly from overuse but also from infection or rheumatic disease.

Myasthenia Gravis: A chronic autoimmune neuromuscular disease that causes weakness in the skeletal muscles, which are responsible for breathing and moving parts of the body, including the arms and legs.