Generic Name: Pantoprazole
Therapeutic Class: Gastrointestinal Agent
Pharmacological Class: Proton Pump Inhibitor
Composition: Each tablet contains Pantoprazole sodium 40 mg
(As delayed-release tablets)
Pregnancy Category: B
Presentation: Available in the pack size as 10 tablets X 20 strips
Pantoprazole is a proton pump inhibitor that decreases the amount of acid produced in the stomach. It is a prodrug.
Mechanism of action
Pantoprazole’s mechanism of action involves the permanent inhibition of proton pumps in the stomach, which are responsible for gastric acid production. It is a prodrug – in the acid environment of the parietal cells, Pantoprazole inhibits the H+, K+ ATPase of the coating gastric cells and gastric acid secretion is suppressed.
- Gastro esophageal reflux disease (GERD)
- NSAID induced gastritis
- Duodenal and Gastric ulcer
- Stress ulcer
- Zollinger-Ellison (ZE) Syndrome
- Hyper secretory Conditions
Route of administration: Oral
- GERD: 40 mg orally once a day 8 weeks
- Reflux esophagitis: 40 mg orally once a day for up to 8 weeks
- Gastric(stomach) Ulcer: 40 mg orally once a day for 4-8 weeks
- Duodenal(intestinal) Ulcer: 40 mg orally once a day for 12 weeks
- Zollinger Ellison Syndrome: 40 mg twice daily, to a maximum of 240 mg per day.
Better efficacy if taken 30 minutes before meal.
- Absorption: Absolute bioavailability is approximately 77%.
- Protein binding: 98% (bound to human plasma proteins)
- Metabolism: Hepatic
- Route of elimination: Approximately 71% of the dose was excreted in the urine with 18% excreted in the feces through biliary excretion
- Half-life: 1 hour
- Gastrointestinal: abdominal pain, diarrhea, flatulence, nausea, vomiting
- Neurologic: headache, dizziness
- Neuromuscular and skeletal: arthralgia
Acidity: Due to its effect of reducing stomach acidity, use of pantoprazole can affect absorption of drugs that are pH-sensitive such as ampicillin esters, ketoconazole, atazanavir, iron salts, amphetamine and mycophenolate mofetil.