(+977) 4110791, 01-4110761 info@opl.com.np

PANOM 40

Generic Name:                                Pantoprazole

Therapeutic Class:                        Gastrointestinal Agent

Pharmacological Class:               Proton Pump Inhibitor

Composition:                                  Each tablet contains Pantoprazole sodium 40 mg

(As delayed-release tablets)

Pregnancy Category:                    B

Presentation:                                  Available in the pack size as 10 tablets X 20 strips

Description

Pantoprazole is a proton pump inhibitor that decreases the amount of acid produced in the stomach. It is a prodrug.

Mechanism of action

Pantoprazole’s mechanism of action involves the permanent inhibition of proton pumps in the stomach, which are responsible for gastric acid production. It is a prodrug – in the acid environment of the parietal cells, Pantoprazole inhibits the H+, K+ ATPase of the coating gastric cells and gastric acid secretion is suppressed.

 

 

 

Indications

  • Gastro esophageal reflux disease (GERD)
  • Heartburn
  • NSAID induced gastritis
  • Duodenal and Gastric ulcer
  • Stress ulcer
  • Zollinger-Ellison (ZE) Syndrome
  • Hyper secretory Conditions

Dosage

Route of administration: Oral

  • GERD: 40 mg orally once a day 8 weeks
  • Reflux esophagitis: 40 mg orally once a day for up to 8 weeks
  • Gastric(stomach) Ulcer: 40 mg orally once a day for 4-8 weeks
  • Duodenal(intestinal) Ulcer: 40 mg orally once a day for 12 weeks
  • Zollinger Ellison Syndrome: 40 mg twice daily, to a maximum of 240 mg per day.

Better efficacy if taken 30 minutes before meal.

Pharmacokinetics

  • Absorption: Absolute bioavailability is approximately 77%.
  • Protein binding: 98% (bound to human plasma proteins)
  • Metabolism: Hepatic
  • Route of elimination: Approximately 71% of the dose was excreted in the urine with 18% excreted in the feces through biliary excretion
  • Half-life: 1 hour

Adverse Effects

  • Gastrointestinal: abdominal pain, diarrhea, flatulence, nausea, vomiting
  • Neurologic: headache, dizziness
  • Neuromuscular and skeletal: arthralgia

Drug Interactions

Acidity: Due to its effect of reducing stomach acidity, use of pantoprazole can affect absorption of drugs that are pH-sensitive such as ampicillin esters, ketoconazole, atazanavir, iron salts, amphetamine and mycophenolate mofetil.