(+977) 4110791, 01-4110761 info@opl.com.np
Generic Name: Orlistat
Therapeutic Category: Dietary Fat Absorption Inhibitor
Pharmacological Class: Lipase Inhibitor
Composition: Each capsule contains Orlistat 120 mg (as pellets)
Pregnancy Category: X
Presentation: Available in the pack size as 10 tablets X 3 blisters

What is Obeslim?

Obeslim contains Orlistat pellets 120 mg in capsule form which is used to treat obesity. Obeslim is certainly your choice in weight loss.

Who should take Obeslim?

  • The patient must have a BMI in excess of 30, or a BMI in excess of 28 which additional risk factors, such as Type 2 diabetes, high cholesterol or hypertension.
  • They should be obese (a BMI of 30 or more) or overweight (a BMI of 27 or more with other risk factors including high cholesterol or type II diabetes).

How does it work?

It works in your digestive system to block about one-third of the fat in the food you eat from being digested. Orlistat attaches to the enzymes in your digestive system (lipases) and mainly blocks them from breaking down some of the fat you have eaten during your meal.

How to take Obeslim?

The usual dose of Orlistat is one 120 mg capsule taken with each of the three main meals per day. It can be taken immediately before, during a meal or up to one hour after a meal. The capsule should be swallowed with water.

Orlistat should be taken with a well-balanced, calorie-controlled diet that is rich in fruit and vegetables and contains an average of 30 % of the calories from fat. Your daily intake of fat, carbohydrate and protein should be distributed over three meals. This means you will usually take one capsule at breakfast time, one capsule at lunchtime and one capsule at dinner time. To gain the optimal benefit, avoid the intake of food containing fat between meals, such as biscuits, chocolate, and savory snacks.

Take Orlistat only under the prescription of a healthcare provider.

What if you miss a dose?

If you forget to take your medicine at any time, take it as soon as you remember provided this is within one hour of your last meal, then continue to take it at the usual times. Do not take a double dose. If you have missed several doses, please inform your doctor and follow the advice given to you.

What do you need to know before you take Orlistat?

Do not take Orlistat:

  • if you are allergic to orlistat or any of the other ingredients of this medicine
  • if you have chronic malabsorption syndrome
  • if you have cholestasis (liver disorder)
  • if you are breast-feeding
  • Reduced gallbladder function (e.g. after cholecystectomy)

Warnings and precautions

  • Discuss with your healthcare provider if you’re taking any other medications. This is because losing weight may mean you need adjustments to the dose of these medicines.
  • To gain the maximum benefit from Obeslim you should follow the nutrition program recommended to you by your doctor. Over-consumption of fat and calories, in contrast, may reduce any weight loss effect.
  • The use of an additional contraceptive method is recommended to prevent possible failure of oral contraception that could occur in case of severe diarrhea.
  • The use of orlistat may be associated with renal stones in patients suffering from chronic kidney disease. Inform your doctor whether you suffer from problems with your kidney.

Children

Orlistat is not intended to be used in children.

Pregnancy and breast-feeding

Taking Orlistat during pregnancy is not recommended. You must not breast-feed your infant during treatment with Orlistat. This is because it is not known whether Orlistat passes into human milk.

Driving and using machines

Orlistat has no known effect on your ability to drive a car or operate machinery.

What are the possible side effects?

Oily discharge, oily or fatty stool, headache, abdominal pain, discomfort, urgent or increased need to open the bowels, flatulence (wind) with or without discharge, liquid stools, low blood sugar levels (experienced by some people with type 2 diabetes), upper respiratory infections, flu (influenza)

Pharmacodyanamic Properties

OBESLIM is the reversible inhibitor of lipases. It exerts its therapeutic activity in the lumen of the stomach & small intestine by forming a covalent bond with the active serine residue site of gastric and pancreatic lipases. This results in unavailability of enzymes to hydrolyze dietary fat in the form of triglycerides into absorbable free fatty acids and monoglycerides. Thus, the fat from the diet is excreted undigested and not absorbed by the body.

Pharmacokinetic Properties:

  • Absorption: Systemic absorption of Orlistat is minimal; however systemic absorption of the drug is not needed for activity.
  • Protein binding: >99% bound to plasma proteins (lipoproteins and albumin were major binding proteins).
  • Metabolism: Metabolized primarily within the gastrointestinal wall forming relatively inactive metabolites.
  • Route of elimination: Fecal
  • Half-life: 1-2 hours

Drug Interactions

Orlistat may modify the activity of:

  • Anticoagulantg. warfarin.
  • Co-administration with ciclosporin is not recommended.
  • Iodine salts and/or levothyroxine; Cases of hypothyroidism
  • Amiodarone
  • Medicines to treat HIV.
  • Orlistat reduces the absorption of supplements of some fat soluble nutrients, particularly beta-carotene and vitamin E. Due to this, multivitamin supplement might be recommended by the healthcare provider.
  • Orlistat may unbalance an anticonvulsant (antiepileptic) treatment, by decreasing the absorption of antiepileptic medicines, thus leading to convulsions.
  • Orlistat is not recommended for people taking acarbose

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