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Medox Content for Website
Generic name: Medroxyprogesterone
Therapeutic Category: Hormones
Pharmacological Class: Progestogen
Composition: Medroxyprogesterone Tablet 10 mg.
Pregnancy Category: X

|What is Medox?

Medox contains Medroxyprogesterone 10mg tablets form.

 

|What is it used for?

Medox is indicated for

  • Dysfunctional uterine bleeding
  • Amenorrhea
  • Hormone replacement therapy
  • Endometrial hyperplasia

 

| How it works?

Medroxyprogesterone (MPA) inhibits the production of gonadotropin, preventing follicular maturation and ovulation, which is responsible for its ability to prevent pregnancy. This action also thins the endometrium. MPA reduces nuclear estrogen receptors and DNA synthesis in epithelial cells of the endometrium.

 

| How to take Medox?

Dysfunctional (an ovulatory) uterine bleeding: 2.5 – 10 mg daily for 5 – 10 days commencing on the assumed or calculated 16th – 21st day of the cycle. Treatment should be given for two consecutive cycles. When bleeding occurs from a poorly developed proliferative endometrium, conventional estrogen therapy may be employed in conjunction with medroxyprogesterone acetate in doses of 5 – 10 mg for 10 days.

Secondary amenorrhea: 2.5 – 10 mg daily for 5 – 10 days beginning on the assumed or calculated 16th to 21st day of the cycle. Repeat the treatment for three consecutive cycles. In amenorrhea associated with a poorly developed proliferative endometrium, conventional estrogen therapy may be employed in conjunction with medroxyprogesterone acetate in doses of 5 – 10 mg for 10 days.

Mild to moderate endometriosis: Beginning on the first day of the menstrual cycle, 10 mg three times a day for 90 consecutive days. Breakthrough bleeding, which is self-limiting, may occur. No additional hormonal therapy is recommended for the management of this bleeding.

 

|What if you miss the dose?

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

 

|What to do in case of over dose?

Contact your health care professional or go to the nearest hospital emergency unit immediately.

 

|What do you need to know before you take Medox?

     Known or suspected pregnancy

Known, past or suspected breast cancer

Previous idiopathic or current venous thromboembolism (deep venous thrombosis, pulmonary embolism)

Active or recent arterial thromboembolic disease (e.g. angina, myocardial infarction)

Acute liver disease or a history of liver disease.

Hypersensitivity to the active substance or to any of the excipients.

 

|Warning and Precautions

A history of, or risk factors for, thromboembolic disorders

Risk factors for estrogen dependent tumors and in following conditions.

  • Hypertension
  • Liver disorders
  • Diabetes mellitus with or without vascular involvement
  • Migraine or (severe) headache
  • Systemic lupus erythematosus.
  • Epilepsy
  • Asthma

 

|Medox and Other Medications

Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines.

 

|Pregnancy and breast- feeding

Pregnancy

Medox should not be used in pregnancy.

Breast – feeding

Medox and its metabolites are secreted in breast milk. Consult your physician before administrating this medication.

 

|Driving and using machines

No effect has been reported.

 

|What are the possible side effects?

Headache (12%) and nausea (10%).