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Kistine

Generic Name

 Ebastine                       

Therapeutic class

 Anti-allergic

Pharmacological Class

Selective H1 antagonist (Second Generation)

Composition

 Ebastine 10:

Each film coated tablet contains Ebastine 10 mg.

Ebastine 20:

Each film coated tablet contains Ebastine 20 mg.

Pregnancy category

‘B’

Presentation

Available in the pack size as 10 tablets X 10 blisters.

What is Kestine?   

Kestine, available as 10 and 20 mg tablets, contains Ebastine, which is an effective anti-allergic medicine used to relieve the symptoms caused by allergic reactions such as hay fever or urticaria (hives). The symptoms may include sneezing, runny nose, itchy eyes, skin rashes, redness of the eyes, etc.

In what conditions Kestine can be used?

·       Allergic Rhinitis

·       Pruritus

·       Dermographic Urticaria

·       Idiopathic Chronic Urticaria

·       Acquired cold urticaria

 

How does Kestine work?         

Activation of receptors of histamine on various tissues produces various allergic symptoms e.g. runny nose.

 Kestine prevents the attachment of histamine on receptors and its activation thus working to manage the symptoms of allergy and related conditions. 

How to take Kestine?

Kestine tablets should be administered orally and the whole tablet has to be swallowed with water (Crushing or chewing the tablet should be strictly avoided).

              

The recommended dosage regimen is;

Adult: 10-20 mg once daily

Child: >6 years: 5 mg once daily

 

                                             

Take Kestine with or without food at around the same time(s) every day. 

Take Kestine exactly as directed. Do not take more or less of it or take it more often or for a longer period of time than prescribed by your doctor.

 

                                       

What to do if a dose is missed?

If you forget to take a dose, take it as soon as you remember. If you don’t remember until it’s nearly time for the next dose, skip the missed dose. Never take two doses at the same time. Never take an extra dose to make up for a forgotten one.

If you often forget doses, it setting an alarm might be helpful to remind you.

                                                        

What do you need to know before you take Kestine?

·       Tell your healthcare provider if you are allergic to any component of the formulation.  

·       Talk to your doctor if you are suffering from cardiac arrhythmias (irregular heartbeat)

 

Do not hesitate to provide information to your healthcare provider about the underlying health conditions that you have and also about other medicines that you are currently taking.

                            

Warnings and Precautions:

·       Take Kestine with precautions if you have any of the following conditions:

§  Hypokalemia (The condition when blood’s potassium levels are too low.)

§  Hepatic impairment

§  Renal impairment

·       Talk to your healthcare provider if you face any discomfort after taking this medicine.

·       Avoid alcohol intake while taking Kestine.        

                                                      

 Can Kestine be taken during pregnancy?

As a precautionary measure, Kestine is not recommended during pregnancy. However, you may consult with your healthcare provider in case of unavoidable use.

          

Can lactating mothers consume Kestine?    

Use of Kestine during breastfeeding is not recommended.

 

Can I drive if I have consumed Kestine?

Do not drive if you experience drowsiness after taking this medicine.

Possible Side effects:             

Common side effects are Headache, Dry mouth, Drowsiness, Pharyngitis, Abdominal pain, Dyspepsia, Asthenia, Epistaxis, Rhinitis, Sinusitis, Nausea, and Insomnia

It does not have systemic anticholinergic side effects and does not cause sedation.

Pharmacodynamics:

 Ebastine, a piperidine derivative, is a long-acting, non-sedating, second-generation histamine receptor antagonist that binds preferentially to peripheral H1 receptors. It is a prodrug and is metabolised to active metabolite, carebastine. It has antihistaminic, anti-allergic activity and prevents histamine-induced bronchoconstriction. It does not have significant sedative or antimuscarinic actions.

Pharmacokinetics:

Absorption: Rapidly absorbed after oral administration

Protein binding: Approximately 95%

Metabolism: Hepatic                  

Route of elimination: Renal

Half-life: The half life of elimination is about 15-19 hours.

                     

Drug Interactions:

  • Concomitant use of ketoconazole, itraconazole, clarithromycin or erythromycin may increase plasma levels of ebastine and cause QTc interval prolongation

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