Generic Name: Mebeverine HCl
Therapeutic Category: Gastrointestinal Anticholinergics/Antispasmodics
Pharmacological Class: Cholinergic muscarinic antagonist
Composition: Each film coated tablet contains Mebeverine HCl 135 mg.
Pregnancy Category: Not Specified
Presentation: Available in the pack size as 10 tablets X 10 blisters
Mebeverine has been investigated for the treatment of Irritable Bowel Syndrome and Post-cholecystectomy* Gastrointestinal Spasms.
Mechanism of Action
Mebeverine is an anticholinergic but its mechanism of action is not known; it appears to work directly on smooth muscle within the gastrointestinal tract and may have an anesthetic effect, may affect calcium channels, and may affect muscarinic receptors. It relieves spasm without affecting normal gut motility.
- Irritable bowel syndrome /Chronic irritable colon / Spastic colon
- Gastrointestinal spasm
- Mucous colitis*
- Spastic constipation
Route of administration: Oral
Children below 10 years: Not Recommended
Adult and child over 10 years: 135–150 mg three times a day preferably 20 minutes before meals.
Absorption: Rapidly absorbed in GIT
Metabolism: Metabolized by esterases
Protein binding: Approximately 11-14%
Route of elimination: Renal
- Hypersensitivity reactions and allergic reactions, immune system disorders, skin disorders including hives, edema and widespread rashes.
- Additionally, the following adverse effects have been reported: heartburn, indigestion, tiredness, diarrhea, constipation, loss of appetite, general malaise, dizziness, insomnia, headache, and decreased pulse rate.
It does not have systemic anticholinergic side effects.
IBOSYN is contraindicated in the following situations:
- Hypersensitivity to the active substance or to any of the excipients.
- Pregnant, lactating mothers
- Children below 10 years
Cholecystectomy: It refers to the surgical removal of the gall bladder.
Mucous colitis: A common gastrointestinal disorder involving an abnormal condition of gut contractions (motility) and gut sensation (hypersensitivity)