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Generic Name Mebeverine Hydrochloride
Therapeutic class Gastrointestinal Anticholinergics/Antispasmodics
Pharmacological Class Cholinergic muscarinic antagonist
Composition  Each film coated tablet contains Mebeverine HCl 135 mg.       
Pregnancy category Not specified
Presentation Available in the pack size as 10 tablets X 10 blisters

What is Ibosyn?     

Ibosyn, available as 135 mg film coated tablets, contains Mebeverine Hydrochloride, which is an antispasmodic and can be used to ease muscle spasms and painful stomach cramps.

In what conditions Ibosyn can be used?

  • Irritable bowel syndrome (IBS)

The main symptoms of IBS include:

  • Stomach pain and spasm
  • Feeling bloated and having wind
  • Having diarrhoea (with or without constipation)
  • Small, hard, pellet-like or ribbon-like stools (faeces)

         These symptoms may vary from person to person.

  • Chronic irritable colon
  • Spastic constipation
  • Mucous colitis
  • Spastic colitis


How does Ibosyn work?                    

Ibosyn works by relaxing certain muscles in your gastrointestinal tract and may have an anesthetic effect. It relieves spasm without affecting normal gut motility.

How to take Ibosyn?

Ibosyn tablets should be administered orally and the whole tablet has to be swallowed with water (Crushing or chewing the tablet should be strictly avoided.)


The recommended dosage regimen is;

Adult and children over 10 years: 135–150 mg three times a day preferably 20 minutes before meals

Take Ibosyn 20 minutes before you have a meal.


Take Ibosyn only under the prescription of a healthcare provider.                                       

What to do if a dose is missed?

If you forget to take a dose, take it as soon as you remember. If you don’t remember until it’s nearly time for the next dose, skip the missed dose. Never take two doses at the same time. Never take an extra dose to make up for a forgotten one.

If you often forget doses, setting an alarm might be helpful to remind you.


What do you need to know before you take Ibosyn?                                                            

Inform your doctor or pharmacist before taking Ibosyn if you have the following conditions:

  • An allergic reaction to any component of the formulation
  • Constipation caused by a condition called paralytic ileus (an inactive gut)
  • A rare inherited condition that means you cannot digest galactose (a sugar found in lactose)

Do not hesitate to provide information to your healthcare provider about the underlying health conditions that you have and also about other medicines that you are currently taking. 

Warnings and Precautions:

Talk to your healthcare provider and use Ibosyn with caution if you:  

  • have lost your appetite or have recently lost weight
  • have unusual vaginal bleeding or vaginal discharge
  • have food poisoning, especially if you have recently travelled abroad

Can Ibosyn be taken during pregnancy?

Ibosyn is not usually recommended in pregnancy. If you’re trying to get pregnant or you’re already pregnant, talk to your doctor about the benefits and possible risks of taking Ibosyn.


Can lactating mothers consume Biospan?                                                   

Use of Ibosyn during breastfeeding is not recommended.


Is Ibosyn safe for use in Children?

Ibosyn can be taken by most adults and children aged 10 years and over. Do not give Ibosyn to children under the age of 10 years.

Effects on ability to drive and use machines

Ibosyn is not expected to affect your driving ability. Do not drive or operate machinery if you experience visual accommodation disturbances after using Ibosyn.

Possible Side effects:     

Some patients have reported dizziness or lightheadedness when taking this treatment. An allergic reaction is unlikely, but you may experience some redness, a rash, or itching. Seek medical help if the symptoms persist or get worse. Seek immediate medical help if you experience difficulties breathing or other severe allergic symptoms like the swelling of your face or tongue and hives.

If you experience any other symptoms, please speak with your doctor or pharmacist for further advice.


Ibosyn is an anticholinergic but its mechanism of action is not known; it appears to work directly on smooth muscle within the gastrointestinal tract and may have an anesthetic effect, may affect calcium channels, and may affect muscarinic receptors. It relieves spasm without affecting normal gut motility.


Absorption: Rapidly absorbed in GIT

Metabolism: Metabolized by esterases

Route of elimination: Renal

Protein binding: Approximately 11-14%


Drug Interactions

It’s safe to take mebeverine with most prescription medicines, and everyday painkillers like paracetamol and ibuprofen.

However, it’s generally best not to take it together with other IBS remedies, as these medicines work in the same way.

There’s very little information about taking herbal medicines and supplements with mebeverine.