Cholinergic Muscarinic Antagonist
Each film coated tablet contains Drotaverine HCl 40 mg.
Each film coated tablet contains Drotaverine HCl 80 mg.
Available in the pack size as 10 tablets X 20 blisters
What is Dove?
Dove, available as 20 and 40 mg film coated tablets, contains Drotaverine Hydrochloride, which is an antispasmodic agent effective to treat spasm or twitches of the smooth muscles in the stomach and heart.
In what conditions you can use Dove?
- Smooth muscle spasm
- Gastrointestinal colic pain
- Renal colic pain
- Uterine neck spasm
- Post MTP(Medical termination of pregnancy)
- Post surgical spasm
- Irritable bowel syndrome
How does Dove work?
Dove acts as a spasmolytic agent; it relaxes smooth muscle cells thus providing relief from spasms and pain.
How to take Dove?
Dove tablets should be administered orally and the whole tablet has to be swallowed with water (Crushing or chewing the tablet should be strictly avoided.)
The recommended dosage regimen is;
- Children aged 1-5 years: 20 mg 3-4 times daily
- Children aged 6 to 12 years: 40 mg three times a day (Maximum dose: 80 mg)
- Adults and children over 12 years: 40-80 mg 3 times/day
Dove can be taken either with or without food.
Take Dove only under the prescription of a healthcare provider.
What to do if a dose is missed?
If you forget to take a dose, take it as soon as you remember. If you don’t remember until it’s nearly time for the next dose, skip the missed dose. Never take two doses at the same time. Never take an extra dose to make up for a forgotten one.
If you often forget doses, setting an alarm might be helpful to remind you.
What do you need to know before you take Dove?
Inform your doctor or pharmacist before taking Dove if you have the following conditions:
- Hypersensitivity to Drotaverine or any component of the formulation
- Cardiac dysfunction
- Renal insufficiency
- Hepatic insufficiency
Do not hesitate to provide information to your healthcare provider about the underlying health conditions that you have and also about other medicines that you are currently taking.
Warnings and Precautions:
- Use of Dove may cause a fall in blood pressure levels and hence should be used with caution in patients having a disease of the heart and blood vessels.
- Caution should be taken among patients with hepatic and renal impairment. Appropriate dose adjustments and safety monitoring are advised if the impairment is severe.
Can Dove be taken during pregnancy?
Dove is not recommended for use by pregnant women unless necessary and the benefits outweigh the risks. Consult your doctor before using this medicine.
Can lactating mothers consume Dove?
Dove is not recommended for use if you are breastfeeding. Consult your doctor and discuss the risks associated with the use of this medicine.
Is Dove safe for use in Children?
Use of Dove is contraindicated for children under the age of 1 year.
Effects on ability to drive and use machines
Though Dove doesn’t have anticholinergic effects, it may cause side effects like dizziness, vertigo, light-headedness in few patients. In such patients, driving and operating heavy machinery should be avoided.
Possible Side effects:
Some of the side effects associated with use of Dove are Dizziness, Vertigo, Headache, Nausea, Vomiting, Palpitation, Constipation, Insomnia, Dry mouth, and Hypotension.
If you experience any other symptoms, please speak with your doctor or pharmacist for further advice.
Drotaverine is a spasmolytic agent by inhibiting PDE4 in smooth muscle cells. It inhibits phosphodiesterases hydrolysing cAMP, thereby increasing cAMP concentration, decreasing Ca uptake of the cells and changing the distribution of calcium among the cells. It may also have minor allosteric calcium channel blocking properties.
Absorption: Rapidly absorbed from the GI tract.
Bioavailability is highly variable.
Protein binding: 80 to 95%
Route of elimination: >50% in urine and ~30% in bile
Half-life: The half life of elimination is 7-12 hours.
- Drotaverine may increase the vasodilatory activities of Isosorbide mononitrate.
The therapeutic efficacy of Drotaverine can be decreased when used in combination with Patent Blue.