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“COQ is immunomodulating natural antioxidant and energy generator which makes you live lively”

COQ 30/60

 

Generic Name:Coenzyme Q10/ Ubidecarenone/ Ubiquinone
Therapeutic Category:    Antioxidant
Composition:COQ 30
 Each capsule contains Ubidecarenone BP 30 mg.
 COQ 60
 Each capsule contains Ubidecarenone BP 60 mg
Presentation:  Available in the pack size as 10 tablets X 3 blisters

What is COQ?

COQ, available as 30 mg and 60 mg Capsules, is an antioxidant. The generic name (A term referring to the chemical makeup of a drug rather than to the advertised brand name under which the drug is sold.) of the product is Ubidecarenone/ Ubiquinone/ Coenzyme Q10.

What is Coenzyme q10?

Coenzyme Q10 (CoQ10) is a nutrient that occurs naturally in the body. CoQ10 acts as an antioxidant, (Antioxidants are substances that may protect your cells against free radicals, which may play a role in heart disease, cancer and other diseases. Free radicals are molecules produced when your body breaks down food or when you’re exposed to tobacco smoke or radiation. ) which protects cells from damage and plays an important part in the metabolism as it helps to generate energy in the cells.

 The highest concentrations of CoQ10 are found in the heart, liver, kidney, and pancreas. The lowest concentrations are found in the lungs. Within the cell, coenzyme Q-10 is mostly present in the mitochondria (40-50%).

The natural production of CoQ10 in the body tends to decrease with age. Fortunately, you can also get CoQ10 through supplements and foods.

Can COQ be taken during pregnancy?

You should stop the supplement if you become pregnant, because the safety of high dose CoQ10 has not been studied in pregnancy.

Can lactating mothers consume coq?

No data exist on the safety and efficacy of supplementation in lactating mothers or infants; hence, it is advised not to consume COQ during lactation period.

What can COQ be used for?

Cardiovascular Diseases:

COQ is essential for well-functioning of your heart. If you have one or more of the following conditions, then you may consume COQ to provide an aid to the restoration of a healthy heart:

  1. High Cholesterol
  2. Heart Surgery
  3. Chronic Heart Failure (CHF)
  4. Angina Pectoris 

Gynecological disorders:

  1. Male Infertility
  2. Pre-eclampsia

Dermatology ( Particularly, skin) :

  1. Prevention of Wrinkles
  2. Rejuvenating Effects

Orthopedic disorders:

Individuals suffering from Muscle cramp, muscle dystrophy, muscle spasm and muscle fatigue

  1. Cancer
  2. Periodontitis
  3. Glaucoma
  4. Migraine
  5. Diabetes

 

How should coq be taken?

Since CoQ10 is fat-soluble, it is recommended to take it with food or use products that combine it with oils to improve its absorption.

 

Adults (19 years and older):

Dosage recommendations for CoQ10 vary depending on individual needs and goals. The recommended dose for CoQ10 supplementation is 30 – 200 mg daily. Higher doses may be recommended for specific conditions. The reference table below provides a general dosage regimen according to the indications in which COQ is used. Please consult with your doctor to determine the right dose for you.

 

IndicationsDosage Regimen
Coenzyme Q10 deficiency         150  mg daily
Heart Failure ( In adults)100 mg per day divided into 2 or 3 doses
High Blood Pressure120-200 mg per day divided into 2 doses
Migraine100 mg three times daily
Infertility in men200-300 mg per day
Muscular dystrophy100 mg per day
HIV/AIDS200 mg per day

 Note: Not recommended for those under 18 years except under the supervision of a health care provider.

 

What are the possible side effects?

Coenzyme Q10 is likely safe for most adults. While most people tolerate coenzyme Q10 well, it can cause some mild side effects that include:

  • Stomach upset, loss of appetite, nausea, vomiting, and diarrhea
  • Allergic skin rashes in some people
  • Lowering of blood pressure, so monitor your blood pressure carefully if you have very low blood pressure.

 

What to do if you miss a dose?

Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.

 

What you need to know before taking COQ?

Ask a doctor, pharmacist, or other healthcare provider if it is safe for you to use Coenzyme Q10 if:

  • you have ever had high or low blood pressure;
  • you are receiving chemotherapy;
  • you smoke

 

Warnings and Precautions

  • Avoid using COQ together with other herbal/health supplements that can also lower blood pressure. Your blood pressure may need to be checked while you are taking COQ.
  • Do not take COQ if you are allergic to Coenzyme Q10 or any ingredients contained in this drug.
  • Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center immediately.
Mechanism of Action:

Ubidecarenone is an essential cofactor in the mitochondrial electron transport chain. Its functions are the acceptance of electrons from the complex I and II and this activity is vital for the production of ATP. It acts as a mobile redox agent shuttling electrons and protons in the electron transport chain. Ubidecarenone also presents antioxidant activity in mitochondria and cellular membranes, protecting against peroxidation of lipid membranes as well as inhibiting oxidation of LDL-cholesterol.

Pharmacokinetics

  • Absorption: Ubidecarenone is absorbed from the small intestine into the lymphatics and then it can enter the blood. The absorption is lower in the presence of an empty stomach and greater in presence of high lipid food diet.
  • Metabolism: Studies indicate that there is no saturation process during the metabolism of ubidecarenone. It is metabolized in all tissues by the phosphorylation in the cells and transportation to the kidneys for further excretion by the urine. After exerting its action, ubidecarenone is reduced and forms hydroquinone which is capable of recycling and regenerates other antioxidants such as tocopherol and ascorbate.
  • Route of elimination: The main elimination route of ubidecarenone is through the bile. After its oral administration, over 60% of the dose is excreted in the feces in the form of unchanged ubidecarenone and a small fraction of the metabolites.In the urine, ubidecarenone is bound to saposin B protein and represents only 8.3% of the total administered dose.
  • Half Life: Studies have reported half-life of ubidecarenone to be 21.7 hours.

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