(+977) 4110791, 01-4110761 info@opl.com.np
“COQ is immunomodulating natural antioxidant and energy generator which makes you live lively”

COQ 30/60

Generic Name:                    Coenzyme Q10/ Ubidecarenone/ Ubiquinone

Therapeutic Category:     Antioxidant

Composition:                      COQ 30

Each capsule contains Ubidecarenone BP 30 mg.

COQ 60

Each capsule contains Ubidecarenone BP 60 mg

Pregnancy Category:        Not Specified

Presentation:                      Available in the pack size as 10 tablets X 3 blisters

Description

Coenzyme Q10 (CoQ10) is a substance that’s found naturally in the body and helps convert food into energy. CoQ10 is found in almost every cell in the body, and it is a powerful antioxidant. Antioxidants fight damaging particles in the body known as free radicals, which damage cell membranes, tamper with DNA, and even cause cell death.

This oil-soluble, vitamin-like substance is present primarily in the mitochondria. (Power-house of cell). It is a component of the electron transport chain and participates in aerobic cellular respiration, generating energy in the form of ATP.

Ninety-five percent of the human body’s energy is generated this way.

Indications

  1. Cardiovascular Diseases:
  • High Cholesterol:

Statins lower cholesterol through inhibition of the mevalonate pathway of cholesterol biosynthesis. With the decrease in cholesterol level, statins also reduce the body’s production of Coenzyme Q10.

  • Heart Surgery
  • COQ help prior to heart surgery, such as bypass operations or heart transplants. It strengthens heart function and lower the possibility of irregular heartbeat, which may occur following heart surgery.
  • Congestive Heart Failure

CoQ10 produces an increased force of heart muscle contraction. It also prevents the accumulation of fatty acids within the heart muscle

  • Angina

Return of blood flow (reperfusion) after coronary artery bypass surgery (a surgical procedure to restore normal blood flow to an obstructed coronary artery) greatly increases the risk of subsequent coronary artery disease because of oxidative damage to the vascular endothelium and myocardium.

  1. Male Infertility:

Both the bioenergetic and the antioxidant role of COQ plays role in sperm biochemistry and male infertility.

  • Provides better sperm motility
  • Repairs the abnormal morphology of sperm that is resulted due to oxidation.
  • Increase in sperm density

 

 

  1. Pre-eclampsia*:
  • Reduces the risk of pre-eclampsia.
  • Vascular endothelium dysfunction may lead to pre-eclampsia.
  1. Muscle cramp, muscle spasm, muscle fatigue and muscle dystrophy:

Cramps can occur when muscles are unable to relax properly due to myosin filaments not fully detaching from actin filaments due to insufficient ATP. The skeletal muscle can tear due to this and increases the pain. Since, Coenzyme act as the bio energizer by generating sufficient ATP, it can thus be helpful in muscle cells.

Muscle dystrophy is a group of muscle disease that has no significant cure. However, the free radical scavenging effect of COQ helps to prevent further damage to muscle fibers.

  1. Dermatology:
  • Rejuvenating and anti-aging

As skin gets older, the fibers that keep skin firm, known as collagen and elastin*, gradually deteriorate. Gradual decline in the natural production of CoQ10 that occurs with age may also weaken the effectiveness of these fibers. Coenzyme Q10 supplementation may reduce the breakdown of collagen.

  1. Others:

Preliminary clinical studies also suggest that CoQ10 may:

  • Improve immune function in people with HIV or AIDS
  • Help prevent migraines
  • Useful in Diabetes
  • Be used as part of the treatment for Parkinson’s disease
  • Help fight cancer
  • Useful in Periodontitis* as it helps scavenge the free radicals causing the disease

Pharmacokinetics

Absorption: Absorbed in small intestine

Metabolism: Limited data available 

Route of elimination: Bile

Half-life: 21.7 hrs

Dosage

Route of administration: Oral

Pediatric: Not recommended for those under 18 years except under the supervision of a health care provider.

Adult: For adults 19 years and older: The recommended dose for CoQ10 supplementation is 30 – 200 mg daily. Higher doses may be recommended for specific conditions.

  • For known coenzyme Q10 deficiency: 150 mg daily
  • Cardiovascular

For heart failure in adults:             100 mg per day divided into 2 or 3 doses.

For high blood pressure: 120-200 mg per day divided into 2 doses.

  • For preventing migraine headache: 100 mg three times daily
  • For infertility in men: 200-300 mg per day
  • For muscular dystrophy: 100 mg per day
  • For HIV/AIDS: 200 mg per day

Adverse Effects

Although it is a naturally available component, misbalance in the body can cause following side effects:

  • Stomach upset
  • Decreased appetite
  • Diarrhea
  • Nausea

Contraindications

COQ 30/60 is contraindicated in the following:

  • Taking coenzyme Q10 with medications, herbs, or supplements that reduce blood pressure may cause too much reduction in blood pressure.
  • It may reduce the blood thinning effect of warfarin.

Precautions

  • Because of the potential for side effects and interactions with medications, you should take dietary supplements only under the supervision of a knowledgeable health care provider.
  • Coenzyme Q10 appears to be generally safe with no major side effects, except occasional stomach upset. However, researchers haven’t done studies and don’t know if CoQ10 supplements are safe during pregnancy and breastfeeding.
  • CoQ10 may lower blood sugar, so people with diabetes should talk with their health care provider before taking it to avoid the risk of low blood sugar.
Terminologies*

  • Preeclampsiais a condition that can develop during pregnancy characterized by high blood pressure (hypertension) and protein in the urine (proteinuria).
  • Collagen and elastin lie under the outer layer of the skin epidermis. Collagen provides strength to the skin and elastin enables the skin to stretch.
  • Periodontitis, caused by certain bacteria, is the inflammation of the gums and supporting structures of the teeth.