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Generic Name  Levodropropizine      
Therapeutic Category       Antitussive
Pharmacological Class Cough Suppressant
Composition  Each 5 ml contains Levodropropizine 30 mg.
Pregnancy category ‘D’
Presentation 100 ml bottle with a measuring cap
What is COFSY-D?   

COFSY-D, available in 100 ml bottle with a measuring cap, each 5 ml of which contains Levodropropizine 30 mg, is a cough suppressant.

For what purposes COFSY-D can be used?

COFSY-D is a medicine used for the symptomatic treatment of a non-productive cough (a dry irritating cough). 


How does COFSY-D work?     

COFSY-D is a cough suppressant that exerts peripheral action and inhibits the afferent pathway that mediates generation of cough reflexes.


How to take COFSY-D?

Route of administration: Oral


As a cough suppressant (Adults): 60 mg of COFSY-D, thrice daily. The duration should not exceed more than seven days.


  • As a cough suppressant (Pediatrics):
    • For children >2 years:1 mg/kg, thrice daily.
    • For children >12 years: consider administration of 60 mg of COFSY-D, thrice daily.

The duration should not exceed more than seven days.


What to do if a dose is missed?

If you forget to take a dose, take it as soon as you remember. If you don’t remember until it’s nearly time for the next dose, skip the missed dose. Never take two doses at the same time. Never take an extra dose to make up for a forgotten one.

If you often forget doses, it setting an alarm might be helpful to remind you.


What do you need to know before you take COFSY-D?

  • Tell your doctor and pharmacist if you are allergic to any component of the formulation.
  • COFSY-D is contraindicated in patients with:
    • limited mucociliary function
    • Severe liver impairment
    • excessive mucus discharge


Do not hesitate to provide information to your healthcare provider about the underlying health conditions that you have and also about other medicines that you are currently taking.


Warnings and Precautions:

  • COFSY-D should be cautiously provided to patients with severe renal impairment.
  • Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • It may cause dizziness or drowsiness, do not drive a car or operate machinery while taking this medication. 


 Can COFSY-D be taken during pregnancy?

 COFSY-D is not recommended during pregnancy. However, you may consult with your healthcare provider in case of unavoidable use.


Can lactating mothers consume COFSY-D?

 COFSY-D is not recommended among lactating mothers.  Consult your healthcare provider before breast-feeding.

 Possible Side effects:             

The symptomatic adverse reactions produced by COFSY-D are more or less tolerable. These include:

Weakness, Dizziness, Headache, Drowsiness, Fatigue, Nausea, Vomiting, Diarrhea, Palpitation, Heart burn, dizziness, Weakness.


Levodropropizine reduces cough by:

  • Peripheral anti-tussive drugs act on chemical and mechanical receptors mainly located in the larynx and trachea lacking effects on the central nervous system, which make them more tolerable.
  • Interfering with stimulus activation of peripheral endings of sensory nerves.
  • Acts as a peripheral antitussive, with no action in the CNS
  • Does not cause side effects such as constipation or respiratory depression which can be produced by opioid antitussives such as codeine and its derivatives.


Absorption: Rapidly absorbed in GIT

Protein binding: Approximately 11-14%

Route of elimination: Renal


Drug Interactions:                              

 May interact with alcohols, sedatives, hypnotics and anti-histamines.