Mechanism of action
Paracetamol is an analgesic and anti-pyretic. It inhibits cyclooxygenase enzyme (COX-1 and COX2) stopping the release of Prostaglandin. Prostaglandins are found in inflammatory exudates and can reproduce the cardinal signs of inflammation, including pain and fever. Blockage of release prostaglandin leads to relieve of fever and pain.
Phenylephrine is a nasal decongestant. It activates Alpha-1 adrenergic receptors of respiratory mucosa causing vasoconstriction. This shrinks swollen mucosal lining of blood vessels and improves ventilation, and increased drainage of the sinus cavities.
Chlorpheniramine Maleate is an antihistamine. It blocks Histamine H1 receptor. Histamine is a chemical found in some of the body’s cells – causes many of the symptoms of allergies, such as a runny nose or sneezing. Thus, blockage of histamine causes relieve from allergies and its symptoms.
This medication must be administered orally.
Adults (18 years or above): The usual recommended dose is 1-2 tablets three to four times a day.
Children (greater than 2 years): The usual recommended dose is 1-2 teaspoonful (5-10 ml) three to four times a day.
Common side effects are: Dizziness, feeling nervous and excitable, fatigue, irritability, insomnia, hallucination, sedation.