(+977) 4110791, 01-4110761 info@opl.com.np
AGT

Generic Name

 Tinidazole                   

Therapeutic class

 Anti-protozoal

Composition

  AGT 500:

Each film-coated tablet contains AGT 500 mg.

 AGT 1000:

Each film-coated tablet contains AGT 1000 mg.

Pregnancy category

‘C’

Presentation

Available in the pack size as 10 tablets X 10 blisters.

What is AGT?

AGT, available as 500 and 1000 mg film-coated tablets, contains AGTwhich is an anti-parasitic drug used against protozoan infections. It is widely known throughout Europe and the developing world as a treatment for a variety of amoebic and parasitic infections.

 

In what conditions AGT can be used?

  • Amebiasis
  • Bacterial Vaginosis (BV)
  • Giardiasis
  • Non-gonococcal urethritis
  • Sexually Transmitted Disease (STD)
  • Trichomoniasis

 

How does AGT work?                 

AGT is an antibiotic that fights bacteria in the body.  It works by killing the organisms that can cause infection.

How to take AGT?

AGT tablets should be administered orally and the whole tablet has to be swallowed with water (Crushing or chewing the tablet should be strictly avoided).

 

Take AGT with food.

 

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

        

The recommended dosage regimen is; 

  • For Amebiasis:

Adults: 2 grams per day for three days.

Children 3 years of age and older: 50 milligrams per kilogram of body weight per day (up to to 2 grams per day) for three days.

  • For bacterial vaginosis (non-pregnant):

Adults: 2 grams per day for two days or 1 gram per day for five days.

  • For giardiasis:

Adults: 2 grams given once as a single dose.

Children 3 years of age and older: 50 milligrams per kilogram of body weight (up to to 2 grams) given once as a single dose.

  • For trichomoniasis:

Adults: 2 grams given once as a single dose.

Take this medication for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared.

No safety & efficacy data on pediatric patients below 3 years of age.

                                       

What to do if a dose is missed?

If you forget to take a dose, take it as soon as you remember. If you don’t remember until it’s nearly time for the next dose, skip the missed dose. Never take two doses at the same time. Never take an extra dose to make up for a forgotten one.

If you often forget doses, it setting an alarm might be helpful to remind you.

                                                        

What do you need to know before you take AGT?

  • Tell your healthcare provider if you:
  • Are allergic to any component of the formulation.  
  • Have anemia or other blood disorders
  • Frequently drink alcohol containing drinks
  • Are receiving hemodialysis
  • Have seizure disorder
  • Have an unusual or allergic reaction to tinidazole, other medicines, foods, dyes, or preservatives

 Do not hesitate to provide information to your healthcare provider about the underlying health conditions that you have and also about other medicines that you are currently taking.

 

Warnings and Precautions:

  • Caution should be taken in patients with history of blood dyscrasias or history of hepatic impairment
  • Do not drink alcoholwhile taking AGT and for at least 3 days after your treatment ends. You may have unpleasant side effects such as fast heartbeats, severe nauseavomiting, sweating, and warmth or tingling under your skin.
  • Check the label of the products and other medicines you use, such as mouthwash or cough and cold medicines. Alcohol in these products can also cause a reaction if you use them while taking AGT.
  • Tell your doctor or health care professional if your symptoms do not improve or if they get worse.
  • If you are being treated for a sexually transmitted disease, avoid sexual contact until you have finished your treatment. Your sexual partner may also need treatment.
  • Risk of bacterial overgrowth with prolonged treatment
  • Do not share this medication with another person, even if they have the same symptoms you have.

                                                           

Can AGT be taken during pregnancy?

 Do not take AGT during the first 3 months of pregnancy. Tell your doctor if you are pregnant or plan to become pregnant during treatment.

 

Can lactating mothers consume AGT?     

 AGT can pass into breast milk and may harm a nursing baby. Do not breast-feed while you are taking AGT and for at least 3 days after your last dose.

You may begin nursing again 3 days after your last dose or AGT. If you use a breast pump during treatment, throw out any milk you collect while taking AGT. Do not feed it to your baby.

 

Possible Side effects:             

Common side effects are:

  • vaginal itching or discharge;
  • nausea, vomiting, loss of appetite, indigestion;
  • constipation, diarrhea, stomach cramps;
  • feeling weak or tired;
  • Headache, dizziness; or.
  • a metallic or bitter taste in your mouth;

Pharmacodynamics:

 Tinidazole is a synthetic antiprotozoal agent. Tinidazole demonstrates activity both in vitro and in clinical infections against the following protozoa: Trichomonas vaginalisGiardia duodenalis (also termed G. lamblia), and Entamoeba histolytica. Tinidazole does not appear to have activity against most strains of vaginal lactobacilli.

Tinidazole is a prodrug and antiprotozoal agent. The nitro group of tinidazole is reduced in Trichomonas by a ferredoxin-mediated electron transport system. The free nitro radical generated as a result of this reduction is believed to be responsible for the antiprotozoal activity. It is suggested that the toxic free radicals covalently bind to DNA, causing DNA damage and leading to cell death. The mechanism by which tinidazole exhibits activity against Giardia and Entamoeba species is not known, though it is probably similar.

Pharmacokinetics:

Absorption:  Rapidly and completely absorbed under fasting conditions. Administration with food results in a delay in absorption.

Protein binding: Approximately 12%

Metabolism: Hepatic                  

Route of elimination: Urine (20–25%), feces (12%)

Half-life: The half life of elimination is about 12-14 hours.

Drug Interactions:          

  • Concomitant use of Tinidazole and Dronabinol/Iopinavir/ Ritonavir is contraindicated.
  • Serious interaction may occur with Apalutamide, Disulfiram, ethanol, fluorouracil, ivosidenib, tucatiniba and voxelotor.