DOVE

Antispasmodic

Drotaverine (INN, also known as drotaverine) is an antispasmodic drug, structurally related to papaverine. Drotaverine is a selective inhibitor of phosphodiesterase-4, and has no anticholinergic effects. Drotaverine has been shown to possess dose-dependent analgesic effects in animal models.

General Info

Generic Name:	Drotaverine HCl
Therapeutic Category:	Antispasmodic
Pharmacological Class:	Cholinergic Muscarinic Antagonist
Composition:	Dove 40 Each film coated tablet contains Drotaverine HCl 40mg. Dove 80 Each film coated tablet contains Drotaverine HCl 80mg.
Pregnancy Category:	C
Presentation:	Available in the pack size as 10 tablets X 20 blisters
Mechanism of Action:	Cyclic AMP (cAMP) is a second messenger to regulate a large number of key processes. Phosphodiesterase (PDE) hydrolyses cAMP, thus decreasing its concentration in the cells. cAMP and Ca++ imbalance results in smooth muscle spasm and pain. Drotaverine has antispasmodic effect mediated via inhibition of phosphodiesterase-IV, specific for smooth muscle. Drotaverine acts to correct cyclic AMP and Ca imbalance at the spastic site, thereby relieving smooth muscle spasm and pain. It has a rapid and direct action on the smooth muscle.
Indications:	Intestinal and Biliary renal colics* Irritable Bowel Syndrome(IBS) Uterine Spasm
Dosage:	Route of administration: Oral Children more than 6 years: 40 mg orally 3 times a day tid. No data regarding the Pediatric dosage details of Drotaverine is available. The medication can be taken with or without food.
Pharmacokinetics :	Absorption: Rapidly absorbed from the GI tract Protein binding: Approximately 80-95% Metabolism: Hepatic Route of elimination: >50% in urine and ~30% in bile Half-life: 7-12 hours
Adverse Effects:	Dizziness, Vertigo, Headache, Nausea, Vomiting, Palpitation, Constipation, Insomnia, Dry mouth, Hypotension
Contraindications:	DOVE is contraindicated in the following conditions: Cardiac dysfunction Renal insufficiency Hepatic insufficiency
Interactions:	No data regarding the interactions of Drotaverine was found.
Terminologies:	Colic: severe pain in the abdomen caused by wind or obstruction in the intestines.