PANOM

General

Pantoprazole is a proton pump inhibitor that decreases the amount of acid produced in the stomach. It is a prodrug.

General Info

Generic Name:	Pantoprazole
Therapeutic Class:	Gastrointestinal Agent
Pharmacological Class:	Proton Pump Inhibitor
Composition:	Each tablet contains Pantoprazole sodium 40 mg (As delayed-release tablets)
Pregnancy Category:	B
Presentation:	Available in the pack size as 10 tablets X 20 strips
Mechanism of action:	Pantoprazole’s mechanism of action involves the permanent inhibition of proton pumps in the stomach, which are responsible for gastric acid production. It is a prodrug – in the acid environment of the parietal cells, Pantoprazole inhibits the H+, K+ ATPase of the coating gastric cells and gastric acid secretion is suppressed.
Indications:	Gastro esophageal reflux disease (GERD) Heartburn NSAID induced gastritis Duodenal and Gastric ulcer Stress ulcer Zollinger-Ellison (ZE) Syndrome Hyper secretory Conditions
Dosage:	Route of administration: Oral GERD: 40 mg orally once a day 8 weeks Reflux esophagitis: 40 mg orally once a day for up to 8 weeks Gastric(stomach) Ulcer: 40 mg orally once a day for 4-8 weeks Duodenal(intestinal) Ulcer: 40 mg orally once a day for 12 weeks Zollinger Ellison Syndrome: 40 mg twice daily, to a maximum of 240 mg per day. Better efficacy if taken 30 minutes before meal.
Pharmacokinetics:	Absorption: Absolute bioavailability is approximately 77%. Protein binding: 98% (bound to human plasma proteins) Metabolism: Hepatic Route of elimination: Approximately 71% of the dose was excreted in the urine with 18% excreted in the feces through biliary excretion Half-life: 1 hour
Adverse Effects:	Gastrointestinal: abdominal pain, diarrhea, flatulence, nausea, vomiting Neurologic: headache, dizziness Neuromuscular and skeletal: arthralgia
Drug Interactions:	Acidity: Due to its effect of reducing stomach acidity, use of pantoprazole can affect absorption of drugs that are pH-sensitive such as ampicillin esters, ketoconazole, atazanavir, iron salts, amphetamine and mycophenolate mofetil.