Analgesic and Antipyretic

OMSPAZ

Chlorzoxazone and paracetamol combined (often branded as Myospaz or Parafon Forte) is an oral medication used for acute, painful musculoskeletal conditions. It acts as a muscle relaxant (chlorzoxazone) and analgesic (paracetamol), relieving spasms, muscle stiffness, back pain, and tension headaches.

General Info

Generic Name:

PARACETAMOL 500 mg + CHLORZOXAZONE 250 MG

Composition:

Each uncoated tablet contains Paracetamol 500 mg + Chlorzoxazone 250 mg

Therapeutic Class:

Analgesic, Antipyretic, Skeletal Muscle Relaxant

Pharmacological Category:

Paracetamol: Non-opioid analgesic and antipyretic
Chlorzoxazone: Centrally acting muscle relaxant

Pack Size:

10 x 10’s tablets

Pregnancy:

Category C (Use with caution)

Lactation:

Not recommended unless clearly needed

Indications:

Musculoskeletal pain & spasms
Back pain, neck pain
Strains, sprains
Post-operative muscle pain
Low backache associated with spasms

MECHANISM OF ACTION:

Muscle Pain / Spasm or Injury
↓
Injury causes inflammation & muscle hyperactivity
↓
Paracetamol blocks prostaglandin synthesis in CNS
↓
↓ Pain & Fever
↓
Chlorzoxazone acts on spinal cord & subcortical brain
↓
Muscle spasm by depressing reflexes
↓
Combined effect:
↓ Muscle pain + ↓ Spasm + Improved mobility

PHARMACOKINETICS:

Property	Paracetamol	Chlorzoxazone
Absorption	Rapidly absorbed orally	Well absorbed orally
Onset of action	~30–60 minutes	1 hour
Metabolism	Liver (via glucuronidation)	Liver (cytochrome P450)
Elimination	Urine (as metabolites)	Urine (as glucuronide/sulfate)
Half-life	2–3 hours	1–2 hours
Absorption	Rapidly absorbed orally	Well absorbed orally