COFSY-D

Anti-Tussive

Levodropropizine is a cough suppressant. It is the levo isomer of dropropizine. It acts as a peripheral antitussive, with no action in the central nervous system.

General Info

Generic Name:	Levodropropizine
Therapeutic Category:	Antitussive
Pharmacological Class:	Cough Suppressant
Composition:	Each 5 ml contains Levodropropizine BP 30 mg.
Pregnancy Category:	D
Presentation:	100 ml bottle with a measuring cap
Mechanism of Action:	It reduces cough by: Peripheral anti-tussive drugs act on chemical and mechanical receptors mainly located in the larynx and trachea lacking effects on the central nervous system, which make them more tolerable. Interfering with stimulus activation of peripheral endings of sensory nerves. Acts as a peripheral antitussive, with no action in the CNS Does not cause side effects such as constipation or respiratory depression which can be produced by opioid antitussives such as codeine and its derivatives.
Indications:	Dry irritating cough
Dosage:	Route of administration: Oral As a cough suppressant (Adults): 60 mg of COFSY-D, thrice daily. The duration should not exceed more than seven days. As a cough suppressant (Pediatrics): For children >2 years: 1 mg/kg, thrice daily. For children >12 years: consider administration of 60 mg of COFSY-D, thrice daily. The duration should not exceed more than seven days.
Pharmacokinetics:	Absorption: Rapidly absorbed in GIT Protein binding: Approximately 11-14% Route of elimination: Renal
Adverse Effects:	The symptomatic adverse reactions produced by COFSY-D are more or less tolerable. These include: Weakness, Dizziness, Headache, Drowsiness, Fatigue, Nausea, Vomiting, Diarrhea, Palpitation, Heart burn, dizziness, Weakness.
Contraindication:	COFSY-D is contraindicated in the following situations: Excessive mucus discharge and limited muco-ciliary function. Severe liver impairment. Should not be given in pregnant and lactating mothers
Interactions:	May interact with alcohols, sedatives, hypnotics and anti-histamines.