Urinary Tract Spasmolytic

UROXATE

Flavoxate is an anticholinergic with anti-muscarinic effects. Its muscle relaxant properties may be due to a direct action on smooth muscle rather than by antagonizing muscarinic receptors.

General Info

Generic Name:	Flavoxate HCl
Therapeutic Category:	Urinary tract spasmolytic
Pharmacological Class:	Phosphodiesterase inhibitor
Composition:	Each film coated tablet contains Flavoxate HCl BP 200 mg.
Pregnancy Category:	B
Presentation:	Available in the pack size as 10 tablets X 10 blisters
Mechanism of Action:	UROXATE exerts a direct relaxant effect on smooth muscles via phosphodiesterase inhibition, providing relief to a variety of smooth muscle spasms. This counteracts smooth muscle spasms of urinary tract.
Indications:	Urinary frequency & incontinence* Cytoscopy/surgery Urethrocystitis/urethrotrigonitis* Bladder spasms due to catheterisation Urinary urgency Symptomatic relief of dysuria Nocturia* Cystitis Urethritis Suprapubic* pain Dysuria Prostatitis
Dosage:	Route of administration: Oral Children <12 years: Not recommended; safety and efficacy not established Children ≥12 years: 100-200 mg PO q6-8hr 18 years and older: 200 mg orally 3 to 4 times daily Medication to be taken after meals.
Pharmacokinetics:	Absorption: Well absorbed from gastrointestinal tract. Protein binding: Approximately 90% Metabolism: Hepatic (rapid metabolism) Route of elimination: Urine (50-60%) Half-life: 2-3 minutes
Adverse Effects:	UROXATE is generally well tolerated, but can potentially cause, vomiting, upset stomach, dry mouth or throat, blurred vision, eye pain, and increased sensitivity of your eyes to light.
Contraindications:	UROXATE is contraindicated in the following conditions: Obstructive conditions: pyloric or duodenal obstruction, obstructive intestinal lesions or ileus, achalasia, gastro-intestinal hemorrhage and obstructive uropathies of the lower urinary tract. Hypersensitivity to Flavoxate hydrochloride or to any of the excipients of Uroxate.
Precautions:	UROXATE must be used cautiously in: Patients with suspected glaucoma, especially closed angle cases
Interactions:	No data regarding the interactions of Flavoxate (HCl) was found.