| Category: |
Gastroenterology, Acid Suppressant (Potassium-Competitive Acid Blocker – P-CAB)
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| Product information: |
Generic Name: VONOPRAZAN
Composition: Each film-coated tablet contains Vonoprazan 10 mg / 20 mg
Pharmacological Category: Potassium-Competitive Acid Blocker (P-CAB)
Pregnancy Category: Not well established (use only if clearly needed)
Lactation: Use with caution
Presentation: 10 x 10’s
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| INDICATIONS : |
- Gastroesophageal reflux disease (GERD)
- Erosive esophagitis
- Peptic ulcer disease (gastric & duodenal ulcers)
- H. pylori eradication (in combination therapy)
- Prevention of NSAID-induced ulcers
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| MECHANISM OF ACTION:: |
Vonoprazan
↓
Competitively blocks K⁺ binding site on H⁺/K⁺-ATPase
↓
Direct inhibition of proton pump
↓
No acid activation required
↓
↓ H⁺ secretion into stomach
↓
↓ Gastric acid production (rapid & sustained)
↓
↓ Gastric irritation & mucosal damage
↓
Faster healing + Rapid symptom relief
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| PHARMACOKINETICS : |
Absorption: Rapid oral absorption
Bioavailability: High
Onset of Action:Within hours (faster than PPIs)
Metabolism: Hepatic (CYP system)
Excretion: Urine and feces
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| DOSAGE INFORMATION: |
GERD / Esophagitis: 10–20 mg once daily
Ulcer treatment: 20 mg once daily
H. pylori regimen: 20 mg twice daily (with antibiotics)
Note: Dose and duration depend on indication
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| SIDE EFFECTS: |
- Diarrhea
- Constipation
- Nausea
- Abdominal discomfort
- Headache
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| PRECAUTIONS : |
Use with caution in patients with:
- Liver disease
- Long-term acid suppression risks
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| MONITORING: |
Long-term use: Vitamin B12 levels, magnesium
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| CONTRAINDICATIONS: |
- Hypersensitivity to Vonoprazan
- Caution with severe hepatic impairment
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