RENOV

General

Vonoprazan is a first-in-class potassium-competitive acid blocker (PCAB) used to treat acid-related diseases like erosive esophagitis, gastroesophageal reflux disease (GERD), and stomach ulcers, often in combination with antibiotics for H. pylori eradication. It is generally more potent and faster-acting than traditional proton pump inhibitors (PPIs).

General Info

Category:	Gastroenterology, Acid Suppressant (Potassium-Competitive Acid Blocker – P-CAB)
Product information:	Generic Name: VONOPRAZAN Composition: Each film-coated tablet contains Vonoprazan 10 mg / 20 mg Pharmacological Category: Potassium-Competitive Acid Blocker (P-CAB) Pregnancy Category: Not well established (use only if clearly needed) Lactation: Use with caution Presentation: 10 x 10’s
INDICATIONS :	Gastroesophageal reflux disease (GERD) Erosive esophagitis Peptic ulcer disease (gastric & duodenal ulcers) H. pylori eradication (in combination therapy) Prevention of NSAID-induced ulcers
MECHANISM OF ACTION::	Vonoprazan ↓ Competitively blocks K⁺ binding site on H⁺/K⁺-ATPase ↓ Direct inhibition of proton pump ↓ No acid activation required ↓ ↓ H⁺ secretion into stomach ↓ ↓ Gastric acid production (rapid & sustained) ↓ ↓ Gastric irritation & mucosal damage ↓ Faster healing + Rapid symptom relief
PHARMACOKINETICS :	Absorption: Rapid oral absorption Bioavailability: High Onset of Action:Within hours (faster than PPIs) Metabolism: Hepatic (CYP system) Excretion: Urine and feces
DOSAGE INFORMATION:	GERD / Esophagitis: 10–20 mg once daily Ulcer treatment: 20 mg once daily H. pylori regimen: 20 mg twice daily (with antibiotics) Note: Dose and duration depend on indication
SIDE EFFECTS:	Diarrhea Constipation Nausea Abdominal discomfort Headache
PRECAUTIONS :	Use with caution in patients with: Liver disease Long-term acid suppression risks
MONITORING:	Long-term use: Vitamin B12 levels, magnesium
CONTRAINDICATIONS:	Hypersensitivity to Vonoprazan Caution with severe hepatic impairment