LOTEMP

General

Paracetamol belongs to a group of medicines known as analgesics, or painkillers. It is used to relieve mild to moderate pain. It is also useful for lowering a raised temperature (fever), such as during a cold or after childhood immunizations. Paracetamol is often recommended as one of the first treatments for pain, as it’s safe for most people to take and side effects are rare.

General Info

Generic Name:	Paracetamol
Therapeutic Category:	Antipyretic and Analgesic
Pharmacological Class:	Centrally acting COX inhibitor
Composition:	Each 5 ml contains Paracetamol IP 125 mg.
Pregnancy Category:	B
Presentation:	Available in 60 ml bottle with a measuring cap
Mechanism of Action:	The mechanism of action of paracetamol is not completely understood. Unlike other NSAIDs, paracetamol does not to inhibit the function of any cyclooxygenase (COX) enzyme outside the central nervous system, and this appears to be the reason why it is not useful as an anti-inflammatory. It does appear to selectively inhibit COX activities in the brain, which may contribute to its ability to treat fever and pain. This activity is not likely to directly inhibit by blocking an active site, but rather by reducing COX, which must be oxidized in order to function.
Indications:	Fever Osteoarthritis Pain Low Back Pain Headache Post-Operative Pain Dental Pain Patent ductus arteriosus* (but evidence for the safety and efficacy of paracetamol for this purpose is lacking)
Dosage:	Route of administration: Oral Adult: 325-650 mg two-three times a day when necessary; not to exceed 3250 mg/day unless directed by the doctor. Children: <6 years: As recommended by the doctor 6-12 years: 325-650 mg two to three times a day when necessary; not to exceed 1.625 g/day for not more than 5 days unless directed by the doctor >12 years: 325-650 mg two to three times a day; not to exceed 3.25 g/day unless directed by the doctor
Pharmacokinetics:	Absorption: Rapidly and almost complete with bioavailability of approximately 25%. Protein binding: Approximately greater than 97.5% Metabolism: Hepatic Route of elimination: Renal Half-life: 1-4 hours
Adverse Effects:	Liver damage Skin reactions Asthma
Contraindications:	LOTEMP is contraindicated in the following populations and situations: Hypersensitivity to paracetamol or any other components of the formulation. Severe active liver disease
Precautions:	In patients with Glucose-6-phosphate dehydrogenase deficiency Chronic malnutrition Diabetes
Drug Interactions:	Barbiturates: Render paracetamol less effective and more toxic Isoniazid: May increase the risk of liver damage when used with paracetamol Warfarin: High dose of paracetamol may increase the effect of warfarin
Terminologies:	Patent ductus arteriosus: A condition that affects newborns when a blood vessel used in developing the lungs fails to close as it normally does.