OMFLAM
Composition:
Ibuprofen-400 mg and Paracetamol-325 mg
Dosage form:
Tablet and Suspension
MOA
Ibuprofen is a potent anti-inflammatory agent with analgesic and antipyretic effect whose effect is further reinforced by paracetamol.
Pharmacokinetics
Ibuprofen: Ibuprofen is absorbed from the gastrointestinal tract and peak plasma concentrations occur about 1 to 2 hours after ingestion.About 1% is excreted in urine as unchanged ibuprofen and about 14% as conjugated ibuprofen. There appears to be little if any distribution into breast milk.
Paracetamol: Paracetamol is readily absorbed from the gastrointestinal tract with peak plasma concentrations occurring about 10 to 60 minutes after oral doses. Paracetamol is distributed into most body tissues. It crosses the placenta and is present in breast milk. Plasma-protein binding is negligible at usual therapeutic concentrations but increases with increasing concentrations. Paracetamol is metabolised predominantly in the liver and excreted in the urine mainly as the glucuronide and sulfate conjugates. Less than 5% is excreted as unchanged paracetamol.
