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A quick answer to hyperacidity,


Generic Name:                                Rabeprazole Sodium

Therapeutic Class:                        Gastrointestinal Agent

Pharmacological Class:               Proton Pump Inhibitor

Composition:                                  Each capsule contains Rabeprazole sodium IP 20mg

Pregnancy Category:                    C

Presentation:                                  Available in the pack size as 10 tablets X 10 strips


Rabeprazole is an antiulcer drug in the class of proton pump inhibitors. It is a prodrug that suppresses gastric acid production in the stomach.

Mechanism of action

Rabeprazole’s mechanism of action involves the permanent inhibition of proton pumps in the stomach, which are responsible for gastric acid production. It is a prodrug – in the acid environment of the parietal cells, rabeprazole inhibits the H+K+ ATPase of the coating gastric cells and gastric acid secretion is suppressed.




  • Reflux esophagitis
  • Gastro esophageal reflux disease (GERD)
  • Non cardiac chest pain
  • NSAIDs induced gastritis
  • Functional dyspepsia
  • Peptic Ulcer Disease (PUD)
  • Helicobacter pylori infection
  • Zollinger-Ellison (ZE) Syndrome


Route of administration: Oral

  • GERD: 20 mg orally once a day up to 4 weeks
  • Reflux esophagitis: 20 mg orally once a day up to 4-8 weeks
  • Gastric (stomach) Ulcer: 20 mg orally once a day for 4-8 weeks
  • Duodenal (intestinal) Ulcer: 20 mg orally once a day up to 4 weeks
  • Zollinger Ellison Syndrome: 60 mg orally once a day
  • Helicobacter Pylori infection: 20 mg orally 2 times a day, taken concomitantly with amoxicillin and clarithromycin for 7 days

Better efficacy if taken 30 minutes before meal.


Absorption: Absolute bioavailability is approximately 52%.

Protein binding: 96.3% (bound to human plasma proteins)

Metabolism: Hepatic

Route of elimination: approximately 90% of the drug was eliminated in the urine.

Half-life: 1-2 hours (in plasma)

Adverse Effects

The most common side effects include headache, nausea, and diarrhea. Others include rashes, flu-like symptoms and infections. (Including by the gastrointestinal pathogen Clostridium difficile)



Rabeprazole is contraindicated in the following populations and situations:

  • People with a known hypersensitivity to rabeprazole, substituted benzimidazoles (which are chemically similar to rabeprazole, like omeprazole), or any other component of the capsule formulation (e.g. certain dyes)


Drug Interactions

  • The acid-suppression effects of rabeprazole, like other PPIs, may interfere with the absorption of drugs that require acid, such as ketoconazole and digoxin.
  • Two medications in the same class as rabeprazole can disturb the conversion of an anticoagulant medication called clopidogrel to its active metabolite.
  • Concurrent use of rilpivirine, a medication used to treat HIV infection; decreases the absorption of rilpivirine.