|Generic Name:||Montelukast Sodium|
|Therapeutic Category:||Anti asthmatic|
|Pharmacological Class:||Leukotriene receptor antagonist|
|Composition:||Each film coated tablet contains Montelukast Sodium IP 10 mg|
|Presentation:||Available in the pack size as 10 tablets X 10 strips|
What is Airy-10 and what is it used for?
Airy-10 contains Montelukast sodium 10 mg in tablet form. Montelukast is a leukotriene receptor antagonist that blocks substances called leukotrienes. It is useful in
- Aspirin-exacerbated respiratory disease (AERD)
- Exercise induced bronchospasm (EIB)
- Allergic rhinitis
How does it work?
Montelukast belongs to a group of medications known as leukotriene receptor antagonists. It is used to prevent and manage asthma symptoms and to relieve the symptoms of seasonal allergies, also known as seasonal allergic rhinitis or hay fever. It works by blocking the effects of leukotrienes, a substance produced by the body in response to certain “triggers” that cause narrowing and swelling of airways in the lungs. Montelukast usually starts to work within one day.
How to take Montelukast (Airy-10)?
Always take this medicine exactly as your healthcare professional has told you.
- You should take only one tablet of Montelukast once a day as prescribed.
- It should be taken even when you have no symptoms or have an acute asthma attack.
For adults 15 years of age and older:
One 10 mg tablet to be taken daily in the evening. This tablet may be taken with or without food. If you are taking this medicine, be sure that you do not take any other products that contain the same active ingredient, montelukast.
This medicine is for oral use. You can take Airy-10 tablets with or without food.
What if you miss a dose?
Try to take this medicine as prescribed. However, if you miss a dose, just resume the usual schedule of one tablet once daily. Do not take a double dose to make up for a forgotten dose
What to do in case of overdose?
Contact your healthcare professional immediately for advice. There were no side effects reported in the majority of overdose reports. The most frequently occurring symptoms reported with overdose in adults and children included abdominal pain, sleepiness, thirst, headache, vomiting, and hyperactivity.
If you stop taking Montelukast (Airy-10)
This medicine can treat your asthma only if you continue to take it. It is important to continue taking this medicine for as long as your doctor prescribes. It will help control your asthma. If you have any further questions on the use of this medicine, ask your doctor or pharmacist.
What do you need to know before you take Montelukast (Airy-10)?
Do not take Airy-10
If you are allergic to montelukast or any of the other ingredients of this medicine
Warnings and precautions
Talk to your healthcare professional before taking Airy-10:
- If your asthma or breathing gets worse, tell your doctor immediately. This oral medicine is not meant to treat acute asthma attacks. If an attack occurs, follow the instructions your doctor has given you. Always have your inhaled rescue medicine for asthma attacks with you.
- It is important that you or your child take all asthma medications prescribed by your doctor. This medicine should not be substituted for other asthma medications your doctor has prescribed for you.
- Any patient on anti-asthma medicines should be aware that if you develop a combination of symptoms such as a flu-like illness, pins and needles or numbness of arms or legs, worsening of pulmonary symptoms, and/or rash, you should consult your doctor.
- You should not take aspirin (acetylsalicylic acid) or anti-inflammatory medicines (also known as non-steroidal anti-inflammatory drugs or NSAIDs) if they make your asthma worse.
- Patients should be aware that various neuropsychiatric events (for example behavior and mood related changes) have been reported in adults, adolescents and children with Montelukast 10 mg tablets. If you or your child develops such symptoms while taking Montelukast 10 mg tablets you should consult your doctor or your child’s doctor.
Pregnancy and breast-feeding
If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.
Pregnancy: Women who are pregnant or intend to become pregnant should consult their doctor before taking this medicine. Your doctor will assess whether you can take this tablet during this time.
Breast-feeding: It is not known if this medicine appears in breast milk. You should consult your doctor before taking this tablet if you are breast-feeding or intend to breast-feed
Driving and using machines
This medicine is not expected to affect your ability to drive a car or operate machinery. However, individual responses to medication may vary. Certain side effects (such as dizziness and drowsiness) that have been reported with Montelukast may affect some patients’ ability to drive or operate machinery.
What are the possible side effects?
Like all medicines, this medicine can cause side effects, although not everybody gets them. The side effects include skin rash, mood changes, tremors, headache, stomach pain, heartburn, upset stomach, nausea, diarrhea, tooth pain, tiredness, fever, stuffy nose, sore throat, cough, and hoarseness.
Mechanism of action:
Montelukast inhibits bronchoconstriction due to antigen challenge. Montelukast is a selective leukotriene receptor antagonist of the cysteinyl leukotriene CysLT 1 receptor. The cysteinyl leukotrienes (LTC 4, LTD 4, LTE 4) are products of arachidonic acid metabolism that are released from various cells, including mast cells and eosinophils. They bind to cysteinyl leukotriene receptors (CysLT) found in the human airway. Binding of cysteinyl leukotrienes to leukotriene receptors has been correlated with the pathophysiology of asthma, including airway edema, smooth muscle contraction, and altered cellular activity associated with the inflammatory process, factors that contribute to the signs and symptoms of asthma. Montelukast binding to the CysLT 1 receptor is high-affinity and selective, preferring the CysLT 1 receptor to other pharmacologically important airway receptors, such as the prostanoid, cholinergic, or beta-adrenergic receptor. Montelukast inhibits physiologic actions of LTD 4 at the CysLT 1 receptors, without any agonist activity.
Absorption: It has been observed that montelukast is quickly absorbed following administration by the oral route. The oral bioavailability documented for the drug is 64%. Furthermore, it seems that having a regular meal in the morning or even a high fat snack in the evening does not affect the absorption of montelukast.
Protein binding: It has been determined that the protein binding of montelukast to plasma proteins exceeds 99%
Volume of distribution: The steady-state volume of distribution recorded for montelukast is an average between 8 to 11 litres.
Metabolism: It has been determined that montelukast is highly metabolized and typically so by the cytochrome P450 3A4, 2C8, and 2C9 isoenzymes. In particular, it seems that the CYP2C8 enzymes play a significant role in the metabolism of the drug. Nevertheless, at therapeutic doses, the plasma concentrations of montelukast metabolites are undetectable at steady state in adults and pediatric patients.
Excretion: It has been reported that montelukast and its metabolites are almost exclusively excreted in the bile and into the feces.
Elimination Half-life: 2.7 to 5.5 hours
Clearance: The plasma clearance documented for montelukast is an average of 45 mL/min when observed in healthy adults.
Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines.
Some medicines may affect how Montelukast works, or Montelukast may affect how other medicines work. Tell your doctor if you are taking the following medicines before starting Montelukast tablets:
- phenobarbital (used for treatment of epilepsy)
- phenytoin (used for treatment of epilepsy)
- rifampicin (used to treat tuberculosis and some other infections)
gemfibrozil (used for treatment of high lipid levels in plasma)