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Mecobal 0.5/1.5
Generic Name: Methylcobalamin
Therapeutic Category: Anti-anemic agent/Vitamin/Nerve Supplement
Composition: Mecobal 0.5
Each film coated tablet contains Methylcobalamin 500 mcg
Mecobal 1.5
Each film coated tablet contains Methylcobalamin 1500 mcg
Pregnancy Category: C
Presentation: Available in the pack size as 10 tablets X 10 strips

What is Mecobal?

Mecobal contains Methylcobalamin 500 mcg (0.5 mg) and Methylcobalamin1500 mcg (1.5 mg) in tablet form.  Methylcobalamin is an active form of vitamin B12.

What is it used for?

  • Neuropathic pain
  • Bell’s palsy
  • Vitamin B12 deficiency
  • Prophylactically after total gastrectomy or total ileal resection
  • Megaloblastic anemia
  • Homocysteinemia
  • Male’s impotence
  • Sleep disturbances

How does it work?

Mecobal works by functioning in the production of a compound called myelin, which covers and protect nerve fibers. Methylcobalamin rejuvenates the damaged neuron. Without enough methylcobalamin, myelin sheath does not form properly due to which nerve fibers suffers and people experience irreversible nerve damage. An intrinsic factor made in the stomach, must be present in the intestinal tract to allow its proper absorption. People lacking this factor show vitamin B12 deficiencies such as pernicious anemia.

How to take Mecobal?

This product should not be used aimlessly for more than one month unless it is effective.

Adult Dosage

The usual adult dosage for oral use is 3 tablets (Mecobal 1.5 mg) daily divided into three doses. The dosage may be adjusted depending on the patient’s age and symptoms.

Children below 12years

0.5 mg once a day before meal

Mecobal tablets can be taken with or without food.


What if you miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.


What to do in case of overdose?

Contact your healthcare professional or go to the nearest hospital emergency unit immediately.


What do you need to know before you take Mecobal?

Do not take Mecobal

If you are allergic to methylcobalamin or any of the other ingredients of this medicine


Warnings and Precautions

Before taking Mecobal, tell your healthcare professional if you

  • Have a genetic condition called optic atrophy
  • Have blood in your urine
  • Have an ongoing infection
  • Have low iron or folate levels
  • Have a bone disease called polycythemia


Pregnancy and breast-feeding

Pregnancy: There are no data available for mecobalamin to be used in pregnant women.

Lactation: There are no data available for mecobalamin to be used in lactating women. However, since vitamin B12 is distributed into breast milk, The American Academy of Pediatrics considers its use to be usually compatible with breast feeding.

What food must be avoided while taking Mecobal?


Alcohol actually decreases levels of B vitamins in the body — especially if you drink a lot. You should avoid or limit alcohol consumption while taking vitamin B12.


Vitamin B12 and Grapefruit Juice

You should avoid eating grapefruit and drinking grapefruit juice while taking vitamin B12.

What are the possible side effects?

Common side effects are headache, itching, swelling, nervousness and anxiousness, involuntary or uncontrollable movements

Serious side effects are low levels of potassium in the blood, congestive heart failure, clots in the arms and legs, life-threatening allergic reaction called anaphylaxis, in which you may have trouble breathing, your tongue swells and/or throat closes up, and your skin breaks out into hives, fluid building up in the lungs.

Mechanism of action:

  1. Methylcobalamin is a kind of endogenous coenzyme B12:

As a coenzyme of methionine synthetase, methylcobalamin plays an important role in transmethylation in the synthesis of methionine from homocysteine.


  1. Methylcobalamin is well transported to nerve cell organelles, and promotes nucleic acid and protein synthesis:

Experiments in rats show that methylcobalamin is better transported to nerve cell organelles than cyanocobalamin and promotes nucleic acid and protein synthesis more than cobamamide does. Experiments with cells from the brain origin and spinal nerve cells in rats also show methylcobalamin to be involved in the synthesis of thymidine from deoxyuridine, promotion of deposited folic acid utilization and metabolism of nucleic acid.


  1. Methylcobalamin promotes axonal transport and axonal regeneration:

In rat models with streptozotocin-induced diabetes mellitus, methylcobalamin normalizes axonal skeletal protein transport in sciatic nerve cells. Methylcobalamin exhibits neuropathologically and electrophysiologically inhibitory effects on nerve degeneration in neuropathies induced by drugs, such as adriamycin, acrylamide, and vincristine (in rats and rabbits), models of axonal degeneration in mice and neuropathies in rats with spontaneous diabetes mellitus.


  1. Methylcobalamin promotes myelination (phospholipid synthesis):

Methylcobalamin promotes the synthesis of lecithin which is the main constituent of medullary sheath lipid. It also increases myelination of neurons in rat tissue culture more than cobamamide does.


  1. Methylcobalamin restores delayed synaptic transmission and diminished neurotransmitters back to normal:

Methylcobalamin restores end-plate potential induction early by increasing nerve fiber excitability in the crushed sciatic nerve in rats. In addition, methylcobalamin normalizes diminished levels of acetylcholine in brain tissue of rats fed with a choline-deficient diet.


Pharmacokinetic properties:

Absorption: Vitamin B12 substances bind to intrinsic factor, a glycoprotein secreted by the gastric mucosa, and are then actively absorbed from the gastrointestinal tract. Absorption is impaired in patients with an absence of intrinsic factor, with a malabsorption syndrome or with disease or abnormality of the gut, or after gastrectomy. Absorption from the gastrointestinal tract can also occur by passive diffusion; little of the vitamin present in food is absorbed in this manner although the process becomes increasingly important with larger amounts such as those used therapeutically.

Protein binding and Distribution: Vitamin B12 is extensively bound to specific plasma proteins called transcobalamins; transcobalamin II appears to be involved in the rapid transport of the cobalamins to tissues. Vitamin B12 is stored in the liver. Vitamin B12 diffuses across the placenta and also appears in breast milk.

Excretion: Vitamin B12 is excreted in the bile, and undergoes extensive enterohepatic recycling; part of a dose is excreted in the urine, most of it in the first 8 hours; urinary excretion, however, accounts for only a small fraction in the reduction of total body stores acquired by dietary means. 40-80% of the cumulative amount of total B12 excreted in the urine by 24 hours after single-dose administration was excreted within the first 8 hrs.

Elimination Half-life: 12.5 hours (single-dose oral administration; calculated from the average of 24-48 hour values)

Drug Interactions

It’s always important to share with your doctor and pharmacist all of the medications you are taking. This includes prescription and over-the-counter (OTC) medications, supplements like vitamins and other dietary supplements (nutritional shakes, protein powders, etc.), herbals, and any illegal and recreational drugs.

Some medications that have serious interactions with Vitamin B12 are chlorambucil, omeprazole, colchicine and the herbal supplement goldenseal.