(+977) 4110791, 01-4110761 info@opl.com.np
Generic Name Albendazole                      
Therapeutic class Anti-helminthic


Composition   Each chewable tablet contains Albendazole 400 mg.
Pregnancy category ‘C’
Presentation Available in the pack size as 20 X 1 X 1.
What is ZOLBEN?

ZOLBEN, available as 400 mg chewable tablet, contains Albendazole, also known as Albendazolum, a medication used for the treatment of a variety of parasitic worm infestations.

What can ZOLBEN be used for?

ZOLBEN is effective first line of treatment against:

  • Flatworms
  • Flukes/trematodes: Fasciolosis
  • Tapeworm/cestodes: Neurocysticercosis, Echinococcosis (Hydatid Disease)
  • Nematodes
  • Enterobiasis (Pinworm infection)
  • Trichuriasis (Whipworm infection)
  • Ascariasis
  • Hookworm
  • Cutaneous larva migrans (caused by Ancylostoma)
  • Filariasis
  • Giardiasis


How does ZOLBEN work?                       

ZOLBEN is an anthelmintic or anti-worm medication. It prevents newly hatched insect larvae (worms) from growing or multiplying in your body.

How to take ZOLBEN?

Route of administration: Oral

You may chew it and swallow with a full glass of water. Take with meal.


The recommended dosage regimen for ZOLBEN tablets in different conditions are;

  • Neurocysticercosis:

More than 60 kg: 400 mg two times day for 8-30 days

Less than 60 kg: 15 mg/kg/day in divided doses for 8-30 days; not to exceed 800 mg/day


  • Hydatid Disease:

More than 60 kg: 400 mg two times a day for 28 days; then, 14 drug-free days for 3 cycles

Less than 60 kg: 15 mg/kg/day divided doses, no more than 800 mg/day for 28 days; then, 14 drug-free days for 3 cycles


  • Ascariasis, Hookworm: 400 mg once
  • Pinworm:400 mg once, repeat in 2 weeks
  • Fluke:10 mg/kg once a day for 7 days
  • Larva Migrans, Cutaneous:400 mg once a day for 3 days


Use ZOLBEN for the full prescribed length of time, even if your symptoms quickly improve. Skipping doses can increase your risk of infection that is resistant to medication. 



What to do if a dose is missed?


If you forget to take a dose, take it as soon as you remember. If you don’t remember until it’s nearly time for the next dose, skip the missed dose. Never take two doses at the same time. Never take an extra dose to make up for a forgotten one.

If you often forget doses, it setting an alarm might be helpful to remind you.


What do you need to know before you take ZOLBEN?


Inform your doctor or pharmacist before taking ZOLBEN if you have the following conditions:


  • Allergy to albendazole, or to similar drugs such as mebendazole.
  • eye problems (especially a problem with your retina);
  • liver disease; or
  • Bone marrow suppression.


ZOLBEN doses are based on weight (especially in children and teenagers). Your dose needs may change if you gain or lose weight.

You may be given other medicines to prevent certain side effects of ZOLBEN, or certain effects that can result when the parasites die within your body.


Warnings and Precautions:


  • ZOLBEN can increase your risk of bleeding or infection. You will need frequent medical tests.
  • This medication may cause liver problems. Because drinking alcohol increases the risk of liver problems, limit alcoholic beverages while using this medication. Your liver function may also need to be checked every 2 weeks.
  • Store at room temperature away from moisture and heat.
  • Do not hesitate to provide information to your healthcare provider about the underlying health conditions that you have and also about other medicines that you are currently taking.



Can ZOLBEN be taken during pregnancy?


ZOLBEN may harm an unborn baby. Use effective birth control to prevent pregnancy while taking this medicine and for at least 3 days after your last dose. Tell your doctor if you become pregnant.

You may need to have a negative pregnancy test before starting this treatment.


Can lactating mothers consume ZOLBEN?


It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk.



Possible Side effects:       


The most common side effects caused by

ZOLBEN are headache and abnormal liver function.

People also experience abdominal pain, nausea or vomiting, dizziness or vertigo, increased intracranial pressure, meningeal signs, temporary hair loss, and fever.

Side effects can be different when treating for hydatid disease versus neurocysticercosis.


As a vermicidal, albendazole causes degenerative alterations in the tegument and intestinal cells of the worm, by binding to the colchicine-sensitive site of tubulin, thus inhibiting its polymerization or assembly into microtubules. The loss of the cytoplasmic microtubules leads to impaired uptake of glucose by the larval and adult stages of the susceptible parasites, and depletes their glycogen stores. Degenerative changes in the endoplasmic reticulum, the mitochondria of the germinal layer, and the subsequent release of lysosomes result in decreased production of adenosine triphosphate (ATP), which is the energy required for the survival of the helminth. Due to diminished energy production, the parasite is immobilized and eventually dies.

Albendazole also has been shown to inhibit the enzyme fumarate reductase, which is helminth-specific. This action may be considered secondary to the effect on the microtubules due to the decreased absorption of glucose. This action occurs in the presence of reduced amounts of nicotinamide-adenine dinucleotide in reduced form (NADH), which is a coenzyme involved in many cellular oxidation-reduction reactions.



  • Absorption: Poorly absorbed in gastrointestinal tract due to its low aqueous solubility, bioavailability <5%
  • Protein Binding: Approximately 70%
  • Metabolism: Hepatic
  • Route of elimination: Bile (humans); Urine (ruminants)
  • Half-life: The half life of elimination is 8-12 hours.


Drug Interactions:

  • The anti-epileptics carbamazepine, phenytoin, and phenobarbital lower the plasma concentration and the half-life of albendazole.
  • The antacid cimetidine heightens serum albendazole concentrations, increases the half-life of albendazole.