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Generic Name:                    Cefixime

Therapeutic Category:     Antibiotic

Pharmacological Class:   Cephalosporin

Composition:                      Xifim 100 DT

Each dispersible tablet contains Cefixime trihydrate equivalent to anhydrous Cefixime USP 100 mg

Xifim 200

Each film-coated tablet contains Cefixime trihydrate equivalent to anhydrous Cefixime USP 100 mg


Each 5 ml of constituted suspension contains Cefixime trihydrate equivalent to anhydrous Cefixime USP 50 mg

Pregnancy Category:        B

Presentation:                      Xifim Tablets

                                                Available in the pack size as 10 tablets X 10 strips


Available in 60 ml bottle with a measuring cap


Cefixime, an antibiotic, is a third-generation cephalosporin. Cefixime is highly stable in the presence of beta-lactamase enzymes. As a result, many organisms resistant to penicillin and some cephalosporin due to the presence of beta-lactamases may be susceptible to cefixime. The antibacterial effect of cefixime results from inhibition of mucopeptide synthesis in the bacterial cell wall.

Mechanism of Action

The bactericidal action of Cefixime is due to the inhibition of cell wall synthesis. It binds to one of the penicillin binding proteins (PBPs) which inhibit the final transpeptidation step of the peptidoglycan synthesis in the bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death.


  • Ear: Otitis caused by Haemophilus influenzae, Moraxella catarrhalis and Streptococcus pyogenes.
  • Sinuses: Sinusitis.
  • Throat: Tonsillitis, pharyngitis caused by Streptococcus pyogenes.
  • Chest and lungs: Bronchitis, pneumonia caused by Streptococcus pneumoniae and Haemophilus influenzae.


Route of administration: Oral

Otitis media: 400 mg/day in single daily dose or divided 12 hourly.

Pharyngitis/Tonsillitis: 400 mg/day in single daily dose or divided 12 hourly.


Absorption: About 40%-50% absorbed orally whether administered with or without food.

Protein binding: Approximately 60 %

Metabolism: Hepatic

Route of elimination: Renal and Biliary

Half-life: 3-4 hours

Adverse Effects

  • Very common: Diarrhea
  • Common: Abdominal pain, dizziness, dyspepsia, fever, flatulence, headache


Xifim is contraindicated in:

  • Hypersensitivity to Cephalosporin class of antibiotics


  • Caution in patients with history of Kidney disease
  • This medication may cause false positive results with certain diabetic urine testing products (cupric sulfate-type). This drug may also affect the results of certain lab tests. Make sure laboratory personnel and all your doctors know you use this drug.
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