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Generic Name

Hyoscine Butylbromide     

Therapeutic class

Antiemetic, antivertigo agent, anticholinergic

Pharmacological Class

Antimuscarinic, belladonna alkaloid


Biospan 10:

 Each film coated tablet contains Hyoscine Butylbromide IP 10mg

Biospan 20:  

Each film coated tablet contains Hyoscine Butylbromide IP 20mg

Pregnancy category



Available in the pack size as 10 tablets X 20 strips

What is Biospan?   

Biospan, available as 10 and 20 mg film coated tablets, contains Hyoscine Butylbromide, which is an antispasmodic agent taken to relieve cramps in the stomach, intestines or bladder.

Is Biospan the medicine you need?

If you are experiencing the spasm type pain or feeling bloated or if you are suffering from period pain cramps, then Biospan can be the right medicine for you.

How does Biospan work?                  

Biospan works by relaxing some of the muscles in your gastrointestinal and urinary systems.

It goes straight to the site of the pain, allowing cramped muscles to gently relax and return to normal and provides targeted and effective relief from abdominal cramping pain and discomfort.

How to take Biospan?

Biospan tablets should be administered orally and the whole tablet has to be swallowed with water (Crushing or chewing the tablet should be strictly avoided.)


The recommended dosage regimen is;

Adults and children over 12 years:  20 mg four times a day

Children aged 6 to 12 years: 10 mg three times a day


For the symptomatic relief of Irritable Bowel Syndrome, the recommended starting dose is 10 mg three times daily, this can be increased up to 20 mg four times daily if necessary.


Biospan can be taken either with or without food.


Take Biospan only under the prescription of a healthcare provider.



What to do if a dose is missed?


If you forget to take a dose, take it as soon as you remember. If you don’t remember until it’s nearly time for the next dose, skip the missed dose. Never take two doses at the same time. Never take an extra dose to make up for a forgotten one.

If you often forget doses, it setting an alarm might be helpful to remind you.


What do you need to know before you take Biospan?


Inform your doctor or pharmacist before taking Biospan if you have the following conditions:


  • Allergic reaction to hyoscine, belladonna alkaloids, or any component of the formulation
  • Enlarged prostate
  • High blood pressure, or if you have recently had a heart attack.
  • Glaucoma
  • Down’s syndrome, Myasthenia Gravis


Do not hesitate to provide information to your healthcare provider about the underlying health conditions that you have and also about other medicines that you are currently taking.


Warnings and Precautions:

  • In case severe, unexplained abdominal pain persists or worsens, or occurs together with symptoms like fever, nausea, vomiting, changes in bowel movements, abdominal tenderness, decreased blood pressure, fainting, or blood in stool, medical advice should immediately be sought.


  • Biospan should not be taken on a continuous daily basis or for extended periods without investigating the cause of abdominal pain.


  • Biospan should be administered with caution to patients with fever as it has the possibility to reduce sweating.


  • Caution should be taken in patients susceptible to intestinal or urinary outlet obstructions and those who have been diagnosed with fast heart rate.


Can Biospan be taken during pregnancy?


As a precautionary measure, Biospan is not recommended during pregnancy. However you may consult with your healthcare provider in case of unavoidable use.

Can lactating mothers consume Biospan?


Use of Biospan during breastfeeding is not recommended.


Is Biospan safe for use in Children?

Biospan can be taken by adults and children over the age of 6 years. Do not give Biospan to children under the age of 6 years.

Effects on ability to drive and use machines

Do not drive or operate machinery if you experience visual accommodation disturbances after using Biospan.

Possible Side effects:     

The table below contains some of the side effects associated with use of Biospan:

 Side-effects (these affect less than 1 in 100 people)

What can I do if I experience this?

Dry mouth

Try chewing sugar-free gum or sucking sugar-free sweets

Dry skin, sweating

If troublesome, ask your doctor for advice

Itchy skin rash

Ask your doctor or pharmacist for further advice in case this is an allergic-type reaction


If you experience any other symptoms such as constipation, fast heart rate or painful red eyes with loss of vision, please speak with your doctor or pharmacist for further advice.


Hyoscine butylbromide is a muscarinic antagonist which acts to prevent acetylcholine-stimulated contraction of smooth muscle in the gastrointestinal tract.

Hyoscine butylbromide binds to muscarinic M3 receptors in the gastrointestinal tract. This prevents acetycholine from binding to and activating the receptors which would result in contraction of the smooth muscle. The inhibition of contraction reduces spasms and their related pain during abdominal cramping.


Absorption: Hyoscine butylbromide has extremely low oral bioavailability with only 0.25-0.82% reaching systemic circulation. It does not cross the blood brain barrier.


Volume of distribution: The volume of distribution is 128 liters.


Metabolism: Hepatic

Route of elimination: Renal

Half-life: The half life of elimination is 1-5 hours.


Drug Interactions

Some products that may interact with this drug include:

  • Certain anti-arrhythmic drugs (e.g., disopyramide, procainamide, quinidine)
  • Anticholinergic drugs (e.g., atropine, glycopyrrolate)
  • Certain antidepressants (tricyclics such as amitriptyline)
  • Other antispasmodic drugs (e.g., clidinium, dicyclomine, propantheline)
  • Certain anti-Parkinson’s drugs (e.g., benztropine, trihexyphenidyl)
  • Belladonna alkaloids
  • MAO inhibitors (isocarboxazid, linezolid, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, selegiline, tranylcypromine)
  • Potassium tablets/capsules